Table 3.
Modified nucleotide residues included in the hammerhead ribozymes
| Name | Ribozyme variant | Included modification | Modification site |
|---|---|---|---|
| RH1-12-2 | RH1 | 8-bromoguanosine | G12 |
| RH1-12-3 | RH1 | arabinoguanosine | G12 |
| RH1-12-4 | RH1 | 8-bromoarabinoguanosine | G12 |
| RH1-12-5 | RH1 | 2′-deoxyguanosine | G12 |
| RH1-12-6 | RH1 | 8-bromo-2′-deoxyguanosine | G12 |
| RH1-12-7 | RH1 | 2′-deoxy-2′-fluoroarabinoguanosine | G12 |
| RH1-12-8 | RH1 | 8-bromo-2′-deoxy-2′-fluoroarabinoguanosine | G12 |
| RH1-12-9 | RH1 | 2-aminoadenosine | G12 |
| RH1-8-2 | RH1 | 8-bromoguanosine | G8 |
| RH1-8-3 | RH1 | arabinoguanosine | G8 |
| RH1-8-4 | RH1 | 8-bromoarabinoguanosine | G8 |
| RH1-8-5 | RH1 | 2′-deoxyguanosine | G8 |
| RH1-8-6 | RH1 | 8-bromo-2′-deoxyguanosine | G8 |
| RH1-8-7 | RH1 | 2′-deoxy-2′-fluoroarabinoguanosine | G8 |
| RH1-8-8 | RH1 | 8-bromo-2′-deoxy-2′-fluoroarabinoguanosine | G8 |
| RH1-8-9 | RH1 | 2-aminoadenosine | G8 |
| RH1-L10 | RH1 | UNA-uridine | U2.2 |
| RH1-L11 | RH1 | UNA-isoguanosine | G2.3 |
| RZ6A-12-2 | RZ6A | 8-bromoguanosine | G12 |
| RZ6A-12-8 | RZ6A | 8-bromo-2′-deoxy-2′-fluoroarabinoguanosine | G12 |
| RZ6C-12-2 | RZ6C | 8-bromoguanosine | G12 |
| RZ6C-12-8 | RZ6C | 8-bromo-2′-deoxy-2′-fluoroarabinoguanosine | G12 |