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. 2022 Jun 22;12:10551. doi: 10.1038/s41598-022-14067-3

Table 3.

Summary of grade 3–4 toxicity of treatment.

Blocks All
A1 B1 C1 A2 B2 C2
Number of evaluable cycles (%) 124 (100) 122 (100) 121 (100) 118 (100) 116 (100) 114 (100) 715 (100)
Hb < 8.0 g/dL 38 (25) 26 (21) 49 (40) 38 (32) 26 (22) 43 (38) 220 (31)
Neutropenia < 1.0 Giga/L 122 (98) 71 (53) 116 (96) 107 (91) 77 (66) 109 (97) 512 (72)
Platelel < 25 Giga/L 76 (61) 10 (8) 71 (57) 75 (64) 23 (21) 73 (65) 328 (49)
Neutropenic fever 61 (49) 20 (16) 32 (26) 25 (26) 24 (21) 32 (28) 214 (27)
Septic shock 3 (2.4) 0 1 (0.8) 0 (0) 0 3 (2.4) 7 (1)
Pneumonia 5 (4) 2 (1.6) 4 (3.2) 3 (2.4) 0 0 14 (2)
Mucositis grade 3/4 16 (13) 38 (31) 16 (13) 20 (17) 26 (22) 15 (13) 113 (18)
Diarrhea grade 3/4 22 (18) 8 (6) 14 (11) 11 (10) 9 (6.3) 18 (16) 82 (11)
Renal toxicity grade 3/4 1 (0.8) 2 (2) 0 (0) 1 (0.8) 0 0 4 (0.50)
Neurological 1 (0.8) 0 2 (1.6) 2 (1.6) 1 (0.8) 0 6 (0.7)
Cardiac grade 3/4 0 3 (2.4) 1 (0.8) 0 0 0 4 (0.5)
Toxic death 0 1 (0.8) 0 0 0 0 1 (0.8)