Table 5.
Multivariable analysis of primary and secondary outcomesa
| Respiratory complication | In-hospital complication | Major complication | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Characteristic | OR | 95% CI | P value | OR | 95% CI | P value | OR | 95% CI | P value |
| DLCO change | |||||||||
| Both normal | — | — | — | — | — | — | |||
| Pre- only | 1.53 | 1.05-2.26 | 0.030 | 1.12 | 0.83-1.52 | 0.5 | 1.00 | 0.59-1.71 | >0.9 |
| Impaired-normal | 3.19 | 1.07-8.57 | 0.027 | 2.09 | 0.79-5.44 | 0.13 | 1.93 | 0.29-7.45 | 0.4 |
| Both impaired | 1.39 | 0.39-3.90 | 0.6 | 0.90 | 0.33-2.20 | 0.8 | 1.86 | 0.41-6.16 | 0.4 |
| Normal-impaired | 2.23 | 1.12-4.29 | 0.019 | 2.83 | 1.55-5.26 | <0.001 | 1.42 | 0.54-3.33 | 0.4 |
| Treatment group | |||||||||
| Full | — | — | — | — | — | — | |||
| Abbreviated | 1.08 | 0.73-1.59 | 0.7 | 1.23 | 0.88-1.70 | 0.2 | 1.09 | 0.64-1.83 | 0.7 |
| ICI | 1.81 | 0.80-3.83 | 0.13 | 1.22 | 0.60-2.44 | 0.6 | 1.40 | 0.45-3.67 | 0.5 |
| Unknown | 1.15 | 0.66-1.94 | 0.6 | 1.09 | 0.70-1.69 | 0.7 | 0.65 | 0.25-1.44 | 0.3 |
| Procedure type | |||||||||
| Lobectomy/bilobectomy | — | — | — | — | — | — | |||
| Pneumonectomy | 0.63 | 0.33-1.12 | 0.14 | 1.30 | 0.84-1.99 | 0.2 | 1.91 | 1.01-3.42 | 0.036 |
| Sublobar | 0.56 | 0.24-1.14 | 0.14 | 0.35 | 0.17-0.65 | 0.002 | 0.15 | 0.01-0.73 | 0.066 |
| Sex | |||||||||
| Female | — | — | — | — | — | — | |||
| Male | 1.68 | 1.19-2.38 | 0.003 | 1.43 | 1.08-1.89 | 0.012 | 1.75 | 1.08-2.87 | 0.024 |
| Approach type | |||||||||
| VATS | — | — | — | — | — | — | |||
| Open | 1.85 | 1.20-2.89 | 0.006 | ||||||
| Surgery year | 1.05 | 1.01-1.08 | 0.004 | ||||||
CI, confidence interval; DLCO, diffusing capacity of the lung for carbon monoxide; ICI, immune checkpoint inhibitor; N/A, not applicable; OR, odds ratio; VATS, video-assisted thoracoscopic surgery.
a
A full univariable analysis is presented in Supplementary Table 10.