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(A) Representative total ion chromatogram (TIC) obtained from the plasma extract of a patient treated with G3139 (5’-TCT CCC AGC GTG CGC CAT- 3’, see text). (B – D) Mass spectra of the fractions eluting with retention times of 13.90, 12.04, and 10.7 min corresponding respectively to the N-1, N-2, and N-3 metabolites generated by stepwise cleavage of the 3’ terminal nucleotides. Reproduced with permission from ref. 148.
