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. Author manuscript; available in PMC: 2024 Jul 1.
Published in final edited form as: Mass Spectrom Rev. 2021 Dec 23;42(4):1332–1357. doi: 10.1002/mas.21766

Figure 8.

Figure 8.

Evaluation of the outcomes observed when submitting the [M − 6H]6- ion of the complex of nogalamycin (Scheme 1) with a model duplex deoxy-ON to either (A) collisionally activated dissociation (CAD) or (B) infrared multi-photon dissociation (IRMPD). The energy imparted to the precursor ion was modulated by varying either the collision voltage (in CAD) or the duration of the laser pulse (in IRMPD). As shown in the legend, fragment types were grouped as single-stranded products, single-stranded with bound drug, deprotonated drug, drug-free duplex, and sequence ions. Reproduced with permission from ref. 229.