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. 2022 Jun 9;13:917998. doi: 10.3389/fimmu.2022.917998

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Copyright © 2022 Di Giorgio and Xodo

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genomic organization of hERV 1464526 in chromosome 16. Typically, as in this case, ERV elements are discontinuous and interspersed with other genomic elements. hERV_1464526 is interposed between three coding genes (ZNRF1, LDHD, ZFP1). The transcript levels as well as H3K4me1, H3K4me3, H3K27ac and Hi-C data were obtained from UCSC genome browser (https://genome.ucsc.edu/) and refer to human embryonic stem cells (hESC). A drop in the transcriptional activity is observed in correspondence to hERV_1464526 locus, in respect to neighbor coding genes. However, the heterochromatinization of ERV locus is not complete, as observed by H3K4me1 levels. Hi-C data evidence the involvement of ERV locus in chromatin looping dynamics and plasticity.