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. 2022 Jun 9;13:873054. doi: 10.3389/fimmu.2022.873054

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Copyright © 2022 Zhang, Lin, Wu, Jin, Li, Peng and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ACT001 inhibits LPS-induced pro-inflammatory factors overproduction. (A) BV-2 cells were administered with LPS and indicated concentrations of ACT001. After 24 h incubation, the effects of ACT001 on LPS-induced NO and cellular viability were measured. (B-E) BV-2 cells were administered with 200 ng/mL LPS and indicated concentrations of ACT001. After 6 h incubation, the effects of ACT001 on LPS induced iNOS (B), IL-1β (C), IL-6 (D) and TNF-α (E) mRNA were measured. All the data represented the mean ± SEM; n, number of independent cell culture preparations = 3. ^#P< 0.05, ^##P< 0.01, ^###P< 0.001 versus the control; *P< 0.05,**P< 0.01, ***P< 0.001 versus the LPS group; ns, not significant.