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. 2022 Jun 9;13:873054. doi: 10.3389/fimmu.2022.873054

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Copyright © 2022 Zhang, Lin, Wu, Jin, Li, Peng and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ACT001 inhibits microglial activation markers expression induced by CCI. The lumbar spinal cords (L4-L6) were collected following the final behavioral testing shown in Figure 6 . These tissues were stained for microglial activation markers. (A-C) Representative immunofluorescence Iba1 images for the sham group (A), CCI group (B), and CCI + ACT001 group (C). (D-F) Representative images for sham group (D), CCI group (E), and CCI + ACT001 group (F) with high magnification (×60). (G-I) The quantification of Iba1 expression was shown as normalized fluorescence intensity (G), number (H), and size of (I) microglia. Scale bar = 200 μm. All the data represented mean ± SEM. ^#P< 0.05, ^##P< 0.01 versus the sham group; *P< 0.05, **P< 0.01 versus the CCI group.