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. 2022 Jun 22;12:10564. doi: 10.1038/s41598-022-14947-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Detection of small allogeneic breast cancer foci (4T1 with tumor size 15 ~ 25 mm³) with L-PEG₂₀₀₀-DBCO. (a,b) side-by-side comparison of tumor uptake obtained by (a) L-PEG₂₀₀₀ and (b) L-PEG₂₀₀₀-DBCO; (c) time course of the biodistribution of L-PEG₂₀₀₀ and L-PEG₂₀₀₀-DBCO in the tumor over 120 h and (d) time course of the biodistribution of L-PEG₂₀₀₀ and L-PEG₂₀₀₀-DBCO in the liver over 120 h.