Figure 1.

Selected areas of interest in the nine bone samples; (a): sample N1, 8 days old, areas of interest 1 and 3 with no signs of bone healing and sharp fracture margins next to the bony trabeculae, areas 2 and 4: healthy bone; (b): sample N5, 28 days old, areas of interest 2 and 3 with woven non-remodeled bone close to fracture line, areas 1 and 4: healthy bone; (c): sample N4, 42 days old, areas of interest 2 and 3 with exaggerated bulging callus accumulating at the periphery, areas 1 and 4: healthy bone; (d): sample N3, 72 days old, areas of interest 2 and 3 with exuberant woven bone formation, areas 1 and 4: healthy bone; (e): sample N2A, 86 days old, areas of interest 2 and 3 with denser woven bone, areas 1 and 4: healthy bone; (f): sample N2B, 86 days old, areas of interest 2 and 3 with signs of advanced healing, including lamellar oriented trabeculae and a smoother appearance of the cortical regions, areas 1 and 4: healthy bone; (g): sample N2C, 86 days old, areas of interest 2 and 3 with lamellar and woven bone, areas 1 and 4: healthy bone; (h): sample N2D, 86 days old, areas of interest 2 and 3 with dense woven callus and complete bridging on the left side, areas 1 and 4: healthy bone; (i): sample N6, 2 years old, areas of interest with 2 and 3 remodeled lamellar bone, areas 1 and 4: healthy bone. Dragonfly software, Version 2020.1.1.809 (academic licence) from Object Research Systems (ORS) Inc, Montreal, Canada, 2020 (software

available at http://www.theobjects.com/dragonfly) was used to generate the volume renderings.