Table 3.
Results of rs-FMRI neuroimaging analyses.
| Contrast seed | Region | MNI coordinates | Statistics | Cluster size | |
|---|---|---|---|---|---|
| x/y/z | t-value | p-value (FWE) | |||
| BL < HC | LGr, ICCr | 14/−72/2 | 5.85 | 0.002 | 112 |
| Seed: bilateral putamen | PreCGl, PreCGr, SFGl, SMAl, PostCGr | −10/−22/80 | 5.69 | <0.001 | 416 |
| PreCGr, MidFGr | 48/8/38 | 5.15 | <0.001 | 205 | |
| PostCGr, pSMGr, SPCr | 42/−34/52 | 4.52 | 0.036 | 67 | |
|
FU < HC Seed: bilateral putamen |
PreCGl, PreCGr, SMAl, SFGr, SFGl, SMAr | −16/−10/70 | 6.29 | <0.001 | 925 |
| IFGopr, FOr | 58/18/8 | 5.98 | 0.005 | 93 | |
| ICr, FOr | 32/22/6 | 5.80 | 0.002 | 110 | |
| aSMGr, pSMGr, PostCGr, SPCr | 58/−36/50 | 5.73 | <0.001 | 332 | |
| PreCGr, MidFGr, IFGopr | 40/10/26 | 5.58 | <0.001 | 266 | |
| POr, pSMGr, PTr, aSMGr | 62/−36/20 | 5.53 | <0.001 | 330 | |
| POl, PTl, SMGl, pSMGl | −60/−32/16 | 5.43 | <0.001 | 298 | |
| aSMGl | −62/−40/44 | 4.59 | 0.012 | 79 | |
|
FU < BL Seed: right caudate |
sLOCl, SPCl, AGl, pSMGl | −30/−66/54 | 6.43 | <0.001* | 357 |
| MTGr, ITGr | 70/−40/−10 | 5.88 | 0.015* | 44 | |
| FPl | −50/42/4 | 5.30 | 0.032* | 33 | |
| ITGl, MTGl | −56/−46/−16 | 5.22 | 0.001* | 71 | |
| FPl, MidFGl | −46/40/22 | 5.06 | 0.032* | 33 | |
Statistical details of rs-fMRI analyses by contrast and seed volumes. Analyses were conducted in CONN as seed-based correlations with bilateral putamina or right caudate nucleus from FDOPA PET comparison (FU < HC; FU < BL) as seeds and compared by unpaired/paired t-tests.
AGI angular gyrus left, ICCr intracalcarine cortex right; ICr right Insula, IFGopr inferior frontal gyrus pars opercularis right, ITGr inferior temporal gyrus right (temporo-occipital); FOr frontal operculum cortex right, FPl frontal pole left, LGr lingual gyrus right, MidFGl middle frontal gyrus left, MidFGr middle frontal gyrus right, MTGl mid temporal gyrus left (temporo-occipital), MTGr mid temporal gyrus right (temporo-occipital), POl parietal operculum cortex left, POr parietal operculum cortex right, PostCGl postcentral gyrus left, PostCGr postcentral gyrus right, PreCGr precentral gyrus right, PreCGl precentral gyrus left, PTl Planum temporale left, PTr planum temporale right, SFGI superior frontal gyrus left, SFGr superior frontal gyrus right, sLOCl superior lateral occipital cortex, SMAl supplementary motor area left, SMAr supplementary motor area right, aSMGl supramarginal gyrus left anterior, aSMGr supramarginal gyrus right anterior, pSMGl supramarginal gyrus left posterior, pSMGr supramarginal gyrus right posterior, SPCl superior parietal cortex left, SPCr superior parietal cortex right, STGl superior temporal gyrus left, STGr superior temporal gyrus right.
*thresholded at cluster-level pFDR < 0.05.