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. 2022 Jun 15;54:102367. doi: 10.1016/j.redox.2022.102367

Fig. 1.

Fig. 1

STING signaling pathway is activated in KCs in LPS-induced septic mice. (A–B) Representative images of immunohistochemistry (IHC) staining for STING protein in Control and LPS (10 mg/kg for 12 h) group. The AOD value of IHC staining was measured by imagePro Plus software (n = 6, 10 + fields per group, bar = 100 μm). (C) Western blot analysis of STING protein expression in KCs and hepatocytes isolated from WT mice (n = 6). (D–G) Western blot analysis of STING, IRF3, p-IRF3, p65 and p-p65 protein expression in KCs isolated from WT mice after Control or LPS treatment (n = 6). (H–J) The mRNA levels of inflammatory cytokines including IFN-β, TNF-α and IL-1β in KCs after Control or LPS treatment (n = 6). Data are expressed as mean ± SEM, *p < 0.05, **p < 0.01, ***p < 0.001.