Fig. 4.

Antigen-specific CD4 T cell responses increase during follow-up. Frequencies of cytokine co-expressing CD4 T cells in peripheral blood of tuberculous pericarditis patients after PPD stimulation in placebo (a) adjunctive prednisolone (b) MIP immunotherapy (c) or combinatorial prednisolone and MIP therapy (d). Frequencies observed in unstimulated blood were subtracted from those in PPD stimulated blood. Horizontal lines of graphs depict the median, boxes the IQR and whiskers the range (Tukey). Wilcoxon comparison of responses at 2 weeks (pink), 6 weeks (royal blue) and 24 weeks (purple) post treatment time points to baseline (light blue). We used the Bonferroni method to account for multiple testing and a p-value below 0.00238 (21 comparisons) was considered significant and highlighted in bold. Only p-values < 0.1 are shown.