Table 1.

Bone mineral content of healthy and disease mouse femurs 3 weeks post-inoculation (mean ± standard deviation) (CTRL n = 7, MET-IPS n = 5, MET-CONTRA n = 5) *p < 0.05, **p < 0.01, ***p < 0.001 relative to CTRL.

		Proximal Femur			Distal Femur
	Units	CTRL	MET-IPS	MET-CONTRA	CTRL	MET-IPS	MET-CONTRA
Cortical bone
Tt. Ar	mm2	1.39 ± 0.06	1.48 ± 0.07	1.41 ± 0.14	0.55 ± 0.03	0.55 ± 0.03	0.58 ± 0.04
Ct. Ar	mm2	1.05 ± 0.05	1.11 ± 0.06	1.07 ± 0.11	0.42 ± 0.02	0.42 ± 0.02	0.44 ± 0.03
Ct.Ar/Tt.Ar	–	0.75 ± 0.02	0.75 ± 0.01	0.76 ± 0.01	0.76 ± 0.02	0.77 ± 0.01	0.76 ± 0.02
Ct.Th	mm	0.1530 ± 0.003	0.1559 ± 0.005	0.1575 ± 0.01	0.1332 ± 0.008	0.1434 ± 0.006*	0.1424 ± 0.006
Mmean	mg HA/cm3	1137.21 ± 5.94	1152.44 ± 12.49*	1149.41 ± 9.50*	1216.93 ± 12.10	1245.9 ± 12.09**	1234.07 ± 9.64*
Mmode	mg HA/cm3	1223.41 ± 6.40	1234.12 ± 13.93	1228.67 ± 12.48	1268.17 ± 10.38	1284.68 ± 7.23*	1284.28 ± 10.40*
M low	%	4.17 ± 1.00	3.04 ± 0.85	2.74 ± 1.09	0.42 ± 0.11	0.37 ± 0.10	0.36 ± 0.07
M medium	%	89.01 ± 5.58	86.23 ± 6.79	84.57 ± 5.80	90.38 ± 7.81	92.29 ± 7.79	95.20 ± 3.68
M high	%	6.82 ± 6.19	10.73 ± 7.40	12.69 ± 6.15	9.20 ± 7.88	7.34 ± 7.86	4.43 ± 3.71
FWHM	mg HA/cm3	253.64 ± 21.87	238.49 ± 9.86	242.69 ± 17.86	196.52 ± 8.93	191.01 ± 12.05	199.28 ± 14.33
Trabecular bone
TV	mm3	2.76 ± 0.18	2.92 ± 0.18	2.84 ± 0.19	2.60 ± 0.15	2.64 ± 0.14	2.71 ± 0.24
BV	mm3	0.48 ± 0.04	0.52 ± 0.06	0.54 ± 0.06	0.39 ± 0.06	0.37 ± 0.09	0.40 ± 0.10
BV/TV	–	0.18 ± 0.02	0.18 ± 0.02	0.19 ± 0.02	0.15 ± 0.02	0.14 ± 0.03	0.14 ± 0.03
Mmean	mg HA/cm3	1122.97 ± 7.30	1137.80 ± 9.65*	1132.10 ± 13.92	1173.73 ± 7.39	1195.8 ± 12.15*	1184.75 ± 8.82
Mmode	mg HA/cm3	1177.78 ± 5.25	1189.43 ± 21.60	1197.19 ± 14.10*	1201.12 ± 10.31	1224.24 ± 5.65**	1218.27 ± 16.92
Conn.D.	mg HA/cm3	102.72 ± 15.35	118.35 ± 12.52	122.64 ± 11.88	230.52 ± 27.02	217.19 ± 40.76	228.24 ± 47.58
SMI	–	0.70 ± 0.12	0.68 ± 0.10	0.57 ± 0.12	1.44 ± 0.15	1.57 ± 0.32	1.44 ± 0.27
Tb.N	1/mm	2.42 ± 0.24	2.48 ± 0.16	2.59 ± 0.15	4.04 ± 0.24	4.11 ± 0.44	4.19 ± 0.42
Tb.Th	mm	0.0619 ± 0.002	0.0591 ± 0.002 *	0.0619 ± 0.003	0.0462 ± 0.002	0.0436 ± 0.001*	0.0437 ± 0.001*
Tb.Sp	mm	0.438 ± 0.05	0.419 ± 0.03	0.410 ± 0.02-	0.239 ± 0.02	0.234 ± 0.03	0.231 ± 0.03
M low	%	1.03 ± 1.25	0.43 ± 0.16	0.50 ± 0.31	0.22 ± 0.12	0.19 ± 0.08	0.38 ± 0.31
M medium	%	93.01 ± 3.18	90.99 ± 5.59	92.37 ± 3.02	96.40 ± 2.69	95.95 ± 1.72	94.66 ± 6.10
M high	%	5.96 ± 3.88	8.58 ± 5.71	7.09 ± 3.19	3.37 ± 2.75	3.87 ± 1.76	4.96 ± 6.26
FWHM	mg HA/cm3	258.14 ± 50.24	241.51 ± 29.13	245.07 ± 20.30	249.65 ± 32.47	251.34 ± 17.63	261.82 ± 29.01