Table 3.

Bone mineral content of healthy and disease mouse femurs 6 weeks post-inoculation (mean ± standard deviation) (CTRL n = 6, MET-IPS n = 7, MET-CONTRA n = 4) *p < 0.05, **p < 0.01, ***p < 0.001 relative to CTRL. †p < 0.05, ††p < 0.01, relative to MET-IPS.

	Units	Proximal Femur			Distal Femur
		CTRL	MET-IPS	MET-CONTRA	CTRL	MET-IPS	MET-CONTRA
Cortical bone
Tt.Ar	mm2	1.59 ± 0.06	1.24 ± 0.28*	1.44 ± 0.08*	0.58 ± 0.02	0.51 ± 0.04**	0.50 ± 0.02**
Ct.Ar	mm2	1.29 ± 0.05	0.94 ± 0.23**	1.13 ± 0.07*	0.48 ± 0.02	0.39 ± 0.05**	0.39 ± 0.02**
Ct.Ar/Tt.Ar	–	0.81 ± 0.004	0.75 ± 0.04**	0.79 ± 0.01*	0.83 ± 0.01	0.77 ± 0.03**	0.77 ± 0.01**
Ct.Th	mm	0.1723 ± 0.004	0.1523 ± 0.010**	0.1565 ± 0.011*	0.1650 ± 0.011	0.1378 ± 0.014**	0.1344 ± 0.003**
Mmean	mg HA/cm3	1187.52 ± 9.76	1197.98 ± 29.10	1174.16 ± 10.27	1286.61 ± 11.64	1287.77 ± 7.52	1290.73 ± 10.15
Mmode	mg HA/cm3	1276.29 ± 6.99	1283.66 ± 19.78	1277.79 ± 3.92	1330.22 ± 8.55	1331.17 ± 8.47	1302.34 ± 35.39
M low	%	2.58 ± 0.45	2.20 ± 1.41	3.00 ± 0.72	0.22 ± 0.06	0.22 ± 0.07	0.18 ± 0.04
M medium	%	88.16 ± 2.19	83.25 ± 6.21	83.26 ± 6.47	76.04 ± 15.15	80.00 ± 17.46	65.12 ± 17.44
M high	%	9.41 ± 2.26	14.54 ± 6.74	13.74 ± 7.11	23.75 ± 15.17	19.78 ± 17.51	34.69 ± 17.48
FWHM	mg HA/cm3	233.87 ± 16.84	229.32 ± 9.06	226.94 ± 16.65	192.55 ± 11.68	177.92 ± 12.35	185.66 ± 15.29
Trabecular bone
TV	mm3	3.57 ± 0.15	4.35 ± 0.46**	4.47 ± 0.20**	3.21 ± 0.06	3.74 ± 0.33**	3.68 ± 0.23**
BV	mm3	0.51 ± 0.03	0.41 ± 0.11	0.52 ± 0.05	0.46 ± 0.05	0.32 ± 0.07**	0.32 ± 0.05*
BV/TV	–	0.14 ± 0.01	0.09 ± 0.02**	0.12 ± 0.01*	0.14 ± 0.02	0.09 ± 0.02***	0.09 ± 0.01**
Mmean	mg HA/cm3	1177.53 ± 9.89	1127.67 ± 17.65***	1133.22 ± 11.97**	1215.72 ± 4.2	1220.38 ± 8.04	1236.51 ± 12.47*†
Mmode	mg HA/cm3	1228.39 ± 6.62	1209.63 ± 14.05*	1224.16 ± 16.46	1247.99 ± 8.38	1257.21 ± 8.83	1269.69 ± 20.73
Conn.D.	mg HA/cm3	64.28 ± 8.31	83.02 ± 15.579	79.27 ± 9.17	140.75 ± 13.59	135.35 ± 40.75	141.63 ± 34.90
SMI	–	0.86 ± 0.03	1.38 ± 0.26***	1.13 ± 0.05**	1.48 ± 0.21	1.97 ± 0.31	2.11 ± 0.14**
Tb.N	1/mm	2.14 ± 0.15	2.14 ± 0.13	2.29 ± 0.29	3.86 ± 0.13	3.51 ± 0.57	3.71 ± 0.31
Tb.Th	mm	0.0611 ± 0.001	0.0454 ± 0.004***	0.0509 ± 0.002*** †	0.0496 ± 0.016	0.0393 ± 0.002**	0.0402 ± 0.001***
Tb.Sp	mm	0.49 ± 0.04	0.47 ± 0.03	0.45 ± 0.06	0.24 ± 0.01	0.29 ± 0.07*	0.26 ± 0.02
M low	%	0.54 ± 0.13	0.97 ± 0.46	1.18 ± 1.23	0.15 ± 0.06	0.12 ± 0.07	0.06 ± 0.02*
M medium	%	93.10 ± 5.62	93.49 ± 2.54	88.80 ± 5.30	94.73 ± 2.69	88.86 ± 9.69	78.81 ± 18.00
M high	%	6.36 ± 5.73	5.54 ± 2.41	10.02 ± 6.26	5.09 ± 2.75	11.01 ± 9.74	23.38 ± 16.14*
FWHM	mg HA/cm3	253.36 ± 24.77	341.28 ± 41.26**	316.14 ± 69.34	267.50 ± 19.50	282.05 ± 18.52	244.09 ± 9.27††