Table 4.
Young's modulus and hardness (mean ± standard deviation) 6 weeks post-inoculation of 4T1 breast cancer cells, obtained from 10 nanoindentation mechanical tests in each region and bone tissue type of each femur. Includes mean ± standard deviation (CTRL n = 6, MET-IPS n = 7, MET-CONTRA n = 4). *p < 0.05, relative to CTRL. †p < 0.05 relative to MET-IPS.
| Proximal Femur |
Distal Femur |
|||||
|---|---|---|---|---|---|---|
| CTRL | MET-IPS | MET-CONTRA | CTRL | MET-IPS | MET-CONTRA | |
| Cortical bone | ||||||
| Young's modulus (GPa) | 19.46 ± 1.20 | 17.61 ± 2.96 | 18.68 ± 0.99 | 17.77 ± 1.75 | 14.39 ± 3.47* | 18.92 ± 2.76* |
| Hardness (GPa) | 0.74 ± 0.07 | 0.70 ± 0.01 | 0.74 ± 0.08 | 0.74 ± 0.05 | 0.67 ± 0.099 | 0.75 ± 0.13 |
| Trabecular bone | ||||||
| Young's modulus (GPa) | 17.96 ± 1.17 | 15.21 ± 2.30* | 18.99 ± 1.48† | 15.56 ± 2.31 | 12.52 ± 3.47 | 14.37 ± 0.59 |
| Hardness (GPa) | 0.73 ± 0.05 | 0.67 ± 0.10 | 0.79 ± 0.04 | 0.67 ± 0.10 | 0.61 ± 0.10 | 0.63 ± 0.07 |