. 2022 Jun 9;9:877220. doi: 10.3389/fmed.2022.877220

TABLE 3.

Univariate and multivariable adjusted odds ratios for rapid eGFR decline.

Variables	Events of RFD (n, %)	Univariate analysis		Multivariable analysis^a
		OR (95% CI) for RFD	P-value	OR (95% CI) for RFD	P-value
RDW ≤ 14.5%	44 (9.50)	Ref		Ref
RDW > 14.5%	21 (35.00)	5.13 (2.77, 9.48)	<0.001	6.79 (3.08, 14.97)	<0.001

Rapid function decline was defined as eGFR loss >5 ml/min/1.73 m²/year.

^aThe model was further adjusted for tubulointerstitial disease as the primary cause of renal failure, usage of iron supplements (yes vs. no), usage of EPO-stimulating agents (yes vs. no), usage of loop diuretics (yes vs. no), usage of alpha-blockers (yes vs. no), usage of calcium-channel blockers (yes vs. no), log (10)-transformed age, percentage of lymphocyte, natural log-transformed baseline eGFR, log (10)-transformed albumin, log (10)-transformed calcium, natural log-transformed UACR, log (10)-transformed 24-h urine protein, and log (10)-transformed LDL-C.

ACEI, angiotensin converting–enzyme inhibitors; ARB, angiotensin II–receptor blockers; CI, confidence interval; eGFR, estimated glomerular filtration rate; EPO, erythropoietin; LDL-C, low-density lipoprotein cholesterol; RDW, red blood cell distribution width; RFD, rapid function decline; OR, odds ratio; UACR, urinary albumin-creatinine ratio.