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. 2022 Jun 9;9:858720. doi: 10.3389/fcvm.2022.858720

FIGURE 1.

FIGURE 1

Gross cardiac histopathology of mice with acute or chronic MI and the post-acute MI survival curve. Images were stained by Carstair’s method in panels (A–D) and by H&E in F, showing hearts from a sham-operated mouse (A) or from a mouse with acute MI and developed CR (B) with a transmural rupture tunnel (indicated by arrows) containing platelet thrombi (*). (C) The heart of a mouse and died of acute heart failure after MI. Note that in the LV chamber, a large blood clot containing a mosaic of platelet-rich white thrombi, the structure suggesting that platelet thrombi were formed prior to death rather than developing postmortem. (D) Heart from a mouse killed on day 3 after MI with severe erosion of the infarct wall (indicated by broken lined square and arrows). The site of erosion was partially filled with platelet-rich thrombi (*) that was coated with dense immune cells. (E) Survival curves of mice with the sham operation (n = 15) or with acute MI (n = 65). Almost all fatalities within the first 2–4 days after MI were due to rupture. (F) The hearts of mice culled in week 4 after MI showed the presence of chronic left ventricular thrombus (LVT).