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. 2022 Jun 9;13:839677. doi: 10.3389/fimmu.2022.839677

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Copyright © 2022 Wu, Quan, Zhang, Wang, Ou, Mao, Sun, Yang, Wu, Wei, Jia, Chen, Zhu, Liu, Zhao, Zhang, Huang, Gao, Tian and Cheng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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m6A-related RNA–protein biology was coordinately and dynamically regulated by DHAV virulence. (A) Commonly regulated GO biological processes in both CH60- and CH strain-infected livers. Basic biological processes, such as mRNA translation, positive regulation of GTP activity, and protein stabilization, are concurrently regulated by both groups. (B) A similar analysis was used to identify commonly regulated KEGG pathways in which proteolysis, ribosome, and aminoacyl-tRNA biosynthesis were enriched. This is partially in line with certain m6A modification on tRNA related fragments in sense and antisense, despite lacking statistical significance between both two groups ( Supplementary Figure 3 ). (C) The dynamic regulation of biological processes of m6A-modified genes was analyzed. During infection, virulence-related mRNA translation and protein metabolism-related pathways were differentially regulated at different infection stages, such as nucleotide metabolism, ribosome, and RNA degradation for mRNA translation, amino acid metabolism, ribosome biosynthesis, and protein processing for protein metabolism.