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. 2022 Jun 9;12:786981. doi: 10.3389/fonc.2022.786981

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Copyright © 2022 Wang, Wei, Hu, Pan, Wu, Wang, Zhang, Shi, Liu, Zhao, Zhu and Ye

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The immune microenvironment of tumor tissue of the imaging genomics cohort (FUSCC) and the FAI cohort B (TCGA). Immune deconvolution showed good consistency between the both cohort. (A) Tumors of high FAI_PTAT patients showed enhanced infiltration of Treg, NK, CD56bright cells, Tem cells, and macrophages, and a reduced infiltration of pDC, Tcm cells, Th17 cells, and mast cells, as well as a lower angiogenesis level compared with low FAI_PTAT patients. (B) Immune deconvolution showed an enhanced infiltration of macrophages, pDC cells, Th1 cells, and DC cells, and a reduced infiltration of Th17 cells, Tcm cells, Treg cells, CD8+ T cells, and NK cells, as well as a lower angiogenesis level in peri-tumor fat. (C) Hypoxia score and immune infiltration score were enhanced in fat of high FAI_PTAT patients.