TABLE 7.
Causes of death within 5 years after HTX – stratified by HbA1c at HTX.
| Parameter | T2DM (n = 121) | HbA1c < 7.0% (n = 67) | HbA1c ≥ 7.0% (n = 54) | Difference | 95% CI | P-value |
| Graft failure, n (%) | 18 (14.9%) | 8 (11.9%) | 10 (18.5%) | 6.6% | –6.3 – 19.5% | 0.312 |
| Acute rejection, n (%) | 1 (0.8%) | 1 (1.5%) | 0 (0.0%) | 1.5% | –1.4 – 4.4% | 0.367 |
| Infection/Sepsis, n (%) | 20 (16.5%) | 7 (10.5%) | 13 (24.1%) | 13.6% | 0.1 – 27.1% | 0.045* |
| Malignancy, n (%) | 5 (4.1%) | 4 (6.0%) | 1 (1.9%) | 4.1% | –2.6 – 10.8% | 0.258 |
| Thromboembolic event/bleeding, n (%) | 6 (5.0%) | 1 (1.5%) | 5 (9.3%) | 7.8% | –0.4 – 16.0% | 0.050 |
| All causes, n (%) | 50 (41.3%) | 21 (31.3%) | 29 (53.7%) | 22.4% | 5.1 – 39.7% | 0.013* |
CI, confidence interval; HbA1c, hemoglobin A1c; HTX, heart transplantation; n, number; T2DM, type 2 diabetes mellitus; *, statistically significant (P < 0.050).