Table 1.

List of drugs utilized in this study.

Inhibitory Effects of Study Drugs on Cytochrome P-450 Isoenzymes						Metabolism Pathway
Agent	CYP 1A2	CYP 2C9	CYP 2C19	CYP 2D6	CYP 3A4	CYP Pathway
Gefitinib	0	0	+	+	0	CYP 2D6 ∗, 3A4∗, 1A2, 2C9, 2C19
Losartan	–	–	–	–	–	CYP 2C9∗, 3A4
Citalopram	0	0	0	+	0	CYP 2D6∗, 2C19∗, 3A4, 2C9
Fluoxetine	+	++	+/++	+++	+/++	CYP2D6∗, 2C9, 2C19
Fluvoxamine	+++	++	+++	+	++	CYP 2D6∗, 2C9, 2C19
Paroxetine	+	+	+	+++	+	CYP 2D6∗, 3A4, 2C9
Sertraline	+	+	+	+/++	+	CYP 2D6∗, 2C9∗, 2C19∗, 1A2, 3A4
Venlafaxine	0	0	0	+	+	CYP 2D6∗, 2C19∗

0 ​= ​minimal/no inhibition ​+ ​= mild/weak inhibition ++ ​= ​moderate inhibition.

+++ ​= ​potent/strong inhibition -- ​= ​unknown ∗ Major CYP Pathway.

Table was adapted from Brown (2008); Lin and Lu, 1998; Nemeroff et al. (1996); Hamelin et al. (1996); Swaisland et al. (2005); Spina et al. (2008); Jin et al. (2016); Xu and Li, 2019; Luong et al. (2021); and the results from the CYP1A2, 2C9, 2C19, 2D6, and 3A4 screening.