Table 1.

Clinical, laboratory and histopathological parameters of the total cohort.

Clinical data	Value
Female sex—no. (%)	2 (28.8)
Age—years	72.6 ± 7.1
PD-1 targeted therapy—no. (%)	6 (85.7)
PD-L1 targeted therapy—no. (%)	1 (14.3)
Laboratory parameters	Value	Normal range
Hemoglobin—g/dL	10.5 ± 1.8	13.5–17.5
Thrombocytes— ×103/μL	290.1 ± 83.6	150–350
Leukocytes— ×103/μL	9 ± 2.8	4–11
TSH—mIU/L	0.8 ± 0.7	0.35–4.94
Sodium—mmol/L	139.7 ± 2.9	136–145
Potassium—mmol/L	4.2 ± 0.6	3.5–4.6
Calcium—mmol/L	2.2 ± 0.2	2.2–2.55
Serum creatinine—mg/dL	3.4 ± 1.6	0.7–1.2
eGFR—mL/min	21.7 ± 11.2	> 60
BUN—mg/dL	52.6 ± 20.7	8–26
CRP—mg/L	44.7 ± 39.1	≤ 5
LDH—U/L	290.4 ± 78.6	125–250
Complement C3c—g/L	1.2 ± 0.2	0.82–1.93
Complement C4—g/L	0.3 ± 0.1	0.15–0.57
Urinary parameters	Value	Normal range
Proteinuria—mg/L	394.4 ± 523.5	<140
Albuminuria/g creatinine—mg/g	182.4 ± 232	<30
Urinary α1-microglobulin—mg/L	47.2 ± 29	<12
Urinary IgG—mg/L	32 ± 49.2	<9.6
Urinary kappa—mg/L	51.7 ± 51.4	<6.8
Urinary lambda—mg/L	22.4 ± 32.8	<3.7
Urinary kappa/lambda—ratio	3.5 ± 1.9	>1 or <5.2
Histopathological findings	Value
Glomerular sclerosis—% of total	10.9 ± 11
IF/TA—%	35 ± 22.5
C1q positivity—no. (%)	0 (0)
C3c positivity—no. (%)	0 (0)

AIN, acute interstitial nephritis; BUN, blood urea nitrogen; C1q, complement factor 1q; C3c, complement factor 3 conversion product; C4, complement factor 4; CRP, C-reactive protein; eGFR, estimated glomerular filtration rate (CKD-EPI); IF/TA, interstitial fibrosis/tubular atrophy; IgG, immunoglobulin G; LDH, lactate dehydrogenase; no., number; PD-L1, programmed cell death protein 1-ligand 1; TSH, thyroid stimulating hormone.