TABLE 8.
Weighted odds ratios (95% confidence intervals) for insulin resistance (HOMA-IR) of participants across quartiles of serum uric acid, stratified analysis by menopause (Pre-menopausal women = 1,245; Post-menopausal women = 1,122).
| Case/Participants | Crudea | Model 1a | Model 2a | |
| Pre-menopausal women† | ||||
| Q1 | 322/1,245 | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) |
| Q2 | 354/1,245 | 2.2 (1.2–4.0) * | 2.5 (1.4–4.7) ** | 2.0 (1.1–3.7) * |
| Q3 | 258/1,245 | 3.2 (1.8–5.7) ** | 3.8 (2.1–6.7) ** | 2.2 (1.1–4.4) * |
| Q4 | 311/1,245 | 8.2 (5.2–13.0) ** | 9.5 (6.1–14.9) ** | 3.5 (2.0–6.0) ** |
| P for trend | < 0.01 | < 0.01 | < 0.01 | |
| Post-menopausal women† | ||||
| Q1 | 303/1,122 | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) |
| Q2 | 285/1,122 | 1.1 (0.5–2.2) | 1.1 (0.5–2.2) | 0.6 (0.3–1.3) |
| Q3 | 257/1,122 | 1.7 (0.8–3.6) | 1.7 (0.8–3.7) | 0.9 (0.4–2.0) |
| Q4 | 277/1,122 | 4.1 (2.0–8.1) ** | 4.2 (2.1–8.6) ** | 1.9 (0.8–4.4) |
| P for trend | < 0.01 | < 0.01 | 0.082 |
aCalculated using binary logistic regression.
†Pre-menopausal women: Q1 (uric acid ≤ 226.00 μmol/L), Q2 (226.00 < uric acid ≤ 267.70 μmol/L), Q3 (267.70 < uric acid ≤ 303.30 μmol/L), and Q4 (uric acid > 303.30 μmol/L).
Post-menopausal women: Q1 (uric acid ≤ 249.80 μmol/L), Q2 (249.80 < uric acid ≤ 291.50 μmol/L), Q3 (291.50 < uric acid ≤ 339.00 μmol/L), and Q4 (uric acid > 339.00 μmol/L).
Model 1 adjusted for race.
Model 2 adjusted for race, body mass index, waist circumference, drinking status, education level, hypertension, serum triglyceride, total cholesterol, and urate-lowering therapy.
*P < 0.05.
**P < 0.01.