Table 2.

Liver ultrasound, enzymes, transient elastography and controlled attenuation parameter results.

	PHIV n = 110	HEU n = 36	HU n = 69	P-value overall	P-value PHIV vs. HEU	P-value HEU vs. HU
TE and CAP [Median (IQR)]
Liver stiffness (kPa)	5.0 (4.4–5.9)	5.1 (4.6–6.1)	5.1 (4.5–5.8)	0.4	0.2	0.2
Liver fibrosis (>7kPa)	8 (7%)	2 (6%)	1 (1%)	0.2	1.0	0.3
CAP (dB/m)	195 (173–223)	171 (157–197)	186 (160–212)	0.01	0.004	0.3
Hepatic steatosis (>248dB/m)	10 (9%)	1 (3%)	1 (1%)	0.08	0.3	0.6
CAP (dB/m) in lean children	190 (173–223)	171 (158–195)	182 (157–203)	0.003	0.2	0.3
Liver enzymes and biomarkers [Median (IQR)]
ALT (U/L)	15 (12–20)	13 (10–15)	12 (10–15)	0.0001	0.002	0.3
Raised ALT	11 (10%)	1 (3%)	0 (0%)	0.008	0.3	0.3
AST (U/L)	24 (21–29)	22 (19–27)	22 (18–24)	0.07	0.3	0.2
APRI	0.20 (0.16–0.23)	0.19 (0.15–0.22)	0.17 (0.15–0.23)	0.8	0.7	0.8-
Raised APRI	2 (3%)	0 (0%)	0 (0%)	0.7	1.0	0.4
FIB-4	0.07 (0.05–0.08)	0.07 (0.06–0.09)	0.08 (0.06–0.10)	0.3	0.2
Liver sonar–hepatic steatosis grade	n = 31	n = 15	n = 34
0	11 (36%)	7 (47%)	25 (74%)	0.009	0.2	0.09
1	19 (61%)	6 (40%)	8 (24%)
2	1 (3%)	2 (13%)	1 (3%)
3	0 (0%)	0 (0%)	0 (0%)