Table 3.
Univariable and multivariable linear regression analyses for predictors of controlled attenuation parameter (CAP) in PHIV children (n = 105).
| Univariable | Multivariable | ||||
|---|---|---|---|---|---|
| Coefficient | P -value | Coefficient | P -value | VIF | |
| Age (years) | +2% | 0.1 | −0.5% | 0.7 | 1.14 |
| Sex (male) | +5% | 0.2 | +0.2% | 1.0 | 1.16 |
| Ethnicity (African) | −8% | 0.2 | −2% | 0.7 | 1.09 |
| Tanner staging ≥ 2 | −4% | 0.6 | - | ||
| BMI z-score | +5% | 0.001 | +6% | 0.001 | 1.22 |
| Waist circumference (cm) | +5% | 0.006 | - | ||
| Waist-hip ratio | +6% | 0.9 | - | ||
| TG (mmol/L) | +5% | 0.2 | - | ||
| Insulin (mIU/mL) | +0.04% | 0.7 | - | ||
| HOMA | +0.2% | 0.6 | - | ||
| ALT (u/L) | +0.3% | 0.2 | - | ||
| CD4, per 100 cells/uL | −1% | 0.04 | −1% | 0.02 | 1.02 |
| Duration of HIV suppression (years) | −1% | 0.008 | −1% | 0.009 | 1.22 |
| Zidovudine | +6.1% | 0.03 | |||
| Lopinavir/ritonavir | +6.6% | 0.02 | |||
ALT, alanine transaminase; HOMA, homeostatic model assessment; PHIV, children with perinatally acquired HIV; TG, triglycerides; Coefficients represent % change in CAP per unit change in input variable; model R2 = 0.23.