Item no	Recommendation	Page #
Title and abstract	1	(a) Indicate the study's design with a commonly used term in the title or the abstract	1
		(b) Provide in the abstract an informative and balanced summary of what was done and what was found	3
Introduction
Background/rationale	2	Explain the scientific background and rationale for the investigation being reported	5
Objectives	3	State‐specific objectives, including any pre‐specified hypotheses	6
Methods
Study design	4	Present key elements of study design early in the paper	6
Setting	5	Describe the setting, locations, and relevant dates, including periods of recruitment, exposure, follow‐up and data collection	7
Participants	6	(a) Give the eligibility criteria, and the sources and methods of selection of participants. Describe methods of follow‐up	8
		(b) For matched studies, give matching criteria and number of exposed and unexposed	‐
Variables	7	Clearly define all outcomes, exposures, predictors, potential confounders, and effect modifiers. Give diagnostic criteria, if applicable	8
Data sources/measurement	8a	For each variable of interest, give sources of data and details of methods of assessment (measurement). Describe comparability of assessment methods if there is more than one group	8
Bias	9	Describe any efforts to address potential sources of bias	17
Study size	10	Explain how the study size was arrived at	Figure 1
Quantitative variables	11	Explain how quantitative variables were handled in the analyses. If applicable, describe which groupings were chosen and why	8
Statistical methods	12	(a) Describe all statistical methods, including those used to control for confounding	8
		(b) Describe any methods used to examine subgroups and interactions	8
		(c) Explain how missing data were addressed	8/17
		(d) If applicable, explain how loss to follow‐up was addressed	8
		(e) Describe any sensitivity analyses	‐
Results
Participants	13a	(a) Report numbers of individuals at each stage of study—for example, numbers potentially eligible, examined for eligibility, confirmed eligible, included in the study, completing follow‐up, and analysed	10/Figure 1
		(b) Give reasons for nonparticipation at each stage	Figure 1
		(c) Consider use of a flow diagram	Figure 1
Descriptive data	14a	(a) Give characteristics of study participants (e.g., demographic, clinical and social) and information on exposures and potential confounders	10
		(b) Indicate number of participants with missing data for each variable of interest	Noted in each table
		(c) Summarise follow‐up time (e.g., average and total amount)	13
Outcome data	15a	Report numbers of outcome events or summary measures over time	10–14
Main results	16	(a) Give unadjusted estimates and, if applicable, confounder‐adjusted estimates and their precision (e.g., 95% confidence interval). Make clear which confounders were adjusted for and why they were included	10–14
		(b) Report category boundaries when continuous variables were categorised	10
		(c) If relevant, consider translating estimates of relative risk into absolute risk for a meaningful time period	‐
Other analyses	17	Report other analyses done—for example, analyses of subgroups and interactions, and sensitivity analyses	10–14
Discussion
Key results	18	Summarise key results with reference to study objectives	15
Limitations	19	Discuss limitations of the study, taking into account sources of potential bias or imprecision. Discuss both direction and magnitude of any potential bias	15–17
Interpretation	20	Give a cautious overall interpretation of results considering objectives, limitations, multiplicity of analyses, results from similar studies and other relevant evidence	15–17
Generalisability	21	Discuss the generalisability (external validity) of the study results	15–19
Other information
Funding	22	Give the source of funding and the role of the funders for the present study and, if applicable, for the original study on which the present article is based	2