(A, B) Wild-type and Il6tg mice were exposed to hypoxia for 3 wk. Rats were injected with either monocrotaline or vehicle diluent. (A, B) The levels of pulmonary endothelial Egfr, caspase 3, (A) and Bad (B) were assessed by confocal imaging. (C) Representative hemodynamics traces of hypoxic Cdh5Cre/+
Egfrfl/fl and Cdh5+/+
Egfrfl/fl mice. (D) Ki-67–expressing ECs and Ki-67 MFI were assessed in lung ECs of the control and Egfr KO mice. n = 5 replicates per condition. Data are shown as mean. *P < 0.05, ***P < 0.005, ****P < 0.001.