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. 2022 Jun 9;13:903755. doi: 10.3389/fimmu.2022.903755

Figure 2.

Figure 2

Genomic context and amino acid alignment of porcine IgG subclasses. The genomic context of the porcine IGH constant region is shown at left. The genes encoding the IgG2 and IgG5 subclasses regions are shaded gray, as these are variable in copy number and/or may not be present depending on an individual’s haplotype. Where applicable, old IgG subclass nomenclature is parenthesized and shown in smaller font below current nomenclature, which is based on Zhang et al., 2020 (10). The flanking genes that encode IgD, IgM, IgE, and IgA are in grey and shown for context. Presently used nomenclature is based on. Gene sizes and intergenic distances are not to scale. The amino acid alignments include the construct sequences used in the present study (“PneoSec”), and genomic sequences from the reference assembly, Sscrofa11 (AEMK02000452), and a previous Yorkshire bacterial artificial chromosome assembly (AB699686 and AB699687) (11). For IgG2b, supporting sequences are from a Xiang pig (XP_IGHG2B) as described by Zhang et al., 2020 and a partial Yorkshire cDNA sequence (U03782). Asterisks (*) at the end of the alignments indicate the termination codons.