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. 2022 Jun 9;13:883650. doi: 10.3389/fmicb.2022.883650

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Copyright © 2022 Lin, Wu, Yang, Lin, Liu, Yu, Yao and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gut microbial community structure before radiotherapy (“start”) in patients who subsequently experienced mild or severe ARIE. (A,B) Alpha-diversity indexes (Shannon and Chao1) of the mild (blue) and severe (red) subgroups. (C) Box plot of inter-group and intra-group Unifrac distance-based ANOSIM. R-value > 0 indicated the inter-group difference was greater than the intra-group difference. (D) PCoA of Unifrac distance of the mild and severe subgroups. (E,F) LEfSe analysis (LDA significance threshold > 3.5) of taxa with the greatest differences in abundance between the severe (red, positive scores) and mild (blue, negative scores) subgroups. ****P < 0.0001.