Table 5.

Event rates and association estimates.

	Overall (n = 34,516)	DOACS (n = 3,044)	Warfarin (n = 31,472)	RR (95% CI)	p -value
Stroke
N patients	34,356	3,004	31,352
N events	1,563 (4.54%)	159 (5.29%)	1,404 (4.47%)	1.27 [0.71, 2.30]	P = 0.42
Systemic Embolism
N patients	34,356	3,004	31,352
N events	721 (2.09%)	102 (3.39%)	619 (1.97%)	1.74 [1.08, 2.80]	P = 0.02
Ischemic stroke
N patients	8,833	653	8,180
N events	250 (2.8%)	22 (3.36%)	228 (2.78%)	0.91 [0.39, 2.08]	P = 0.82
Hemorrhagic stroke
N patients	34,356	3,004	31,352
N events	258 (0.75%)	23 (0.76%)	235 (0.74%)	0.53 [0.09, 3.25]	P = 0.49
Major bleeding
N patients	34,516	3,044	31,472
N events	1,167 (3.38%)	164 (5.38%)	1,002 (3.18%)	1.31 [0.90, 1.91]	P = 0.16
Minor bleeding
N patients	8,993	693	8,300
N events	230 (2.55%)	47 (6.78%)	183 (2.2%)	1.52 [1.07, 2.15]	P = 0.02
GI bleeding
N patients	34,516	3,044	31,472
N events	1,355 (3.92%)	201 (6.6%)	1,154 (3.66%)	1.26 [0.75, 2.11]	P = 0.37
Hemodialysis access site bleeding
N patients	8,743	607	8136
N events	2789 (31.89%)	187 (30.8%)	2602(31.9%)	1.05 [0.93, 1.19]	P = 0.45
Death
N patients	34,352	3,004	31,352
N events	1,607 (4.67%)	342 (11.38%)	1,607(5.12%)	1.72 [1.16, 2.55]	P < 0.006

DOACS, direct oral anticoagulants; GI bleeding, gastrointestinal bleeding: SE, systemic embolism; RR, risk ratio; CI, confidence interval.