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. 2022 Apr 7;14(2):245–270. doi: 10.1016/j.jcmgh.2022.04.002

Figure 9.

Figure 9

Overexpression of TM9SF4 decreased M1 macrophage polarization but increased M2 macrophage polarization. (A) Raw264.7 cells overexpressing TM9SF4 or control plasmids were treated with LPS/IFNγ to induce M1 polarization. The mRNA levels of IL23p19, IL6, TNFα, and iNOS were assessed by qRT-PCR (n = 4–6). (B) Raw264.7 cells overexpressing TM9SF4 or control plasmids were treated with IL4/IL13 to induce M2 polarization. The mRNA levels of MRC1, Ym1, IL10, and Arg1 were determined by qRT-PCR (n = 3–6). Means ± SEM. ∗∗P < .01, ∗∗∗P < .001. pcDNA, plasmid cloning DNA.