Table 1.
List of 24 chemicals
| Chemical namea | CAS RN | M.W. | NT | HT | CT | GT | TT | NGC |
|---|---|---|---|---|---|---|---|---|
| Acetonylacetone | 110-13-4 | 114.14 | Nervous System Diseases [LoPachin et al., 2002] | NA | NA | NA | NA | NA |
| Acrylamide | 79-06-1 | 71.08 | Nervous System Diseases [LoPachin et al., 2002] | Liver Diseases [Allam et al., 2010] | NA | NA | NA |
Group B2 https://www.epa.gov/iris |
| Amiodarone | 1951-25-3 | 645.3 | Cerebellar Diseases [Abarbanel et al., 1987] |
DILIrank: 8 (Most-DILI-Concern) LiverTox: Likelihood score: A |
Cardiotoxicity [Clements et al., 2015] | Glomerulonephritis, Membranous [Kimura et al., 2008] | NA | NA |
| AmitriptylineHCl | 549-18-8 | 313.9 | Nervous System Diseases [Sudoh et al., 2004] |
DILIrank: 5 (Less-DILI-Concern) LiverTox: Likelihood score: B |
Arrhythmias, Cardiac [Srinivasa et al., 2003] | NA | NA | NA |
| Atorvastatin | 134523-00-5 | 558.6 | Hemorrhagic Stroke [https://www.drugs.com/sfx/atorvastatin-side-effects.html] |
DILIrank: 5 (Most-DILI-Concern) LiverTox: Likelihood score: A |
NA | NA | NA | NA |
| Axitinib | 319460-85-0 | 386.5 | NA | LiverTox: Likelihood score: E |
Cardiotoxicity [Clements et al., 2015] Heart disease [Lin and Will, 2012] |
Proteinuria [https://www.drugs.com/sfx/axitinib-side-effects.html] |
NA | NA |
| Bucillamine | 65002-17-7 | 223.3 | NA | NA | NA | Nephrotic Syndrome [Ohno, 2004] | NA | NA |
| Butylated HA | 25013-16-5 | 180.24 | NA | NA | NA | NA | NA |
Group 2B PrecancerousConditions [Hirose et al., 1990] |
| Chlorpheniramine | 132-22-9 | 274.79 | NA | DILIrank: 0 (No-DILI-Concern) LiverTox: Likelihood score: E |
NA | NA | NA | NA |
| Chlorpromazine | 50-53-3 | 318.9 | Parkinsonian Disorders [Ferguson and Paule, 1992] | DILIrank: 2 (Less-DILI-Concern) LiverTox: Likelihood score: A |
Cardiomyopathies [Saito et al., 1985] | NA | NA | NA |
| Cisplatin | 15663-27-1 | 300.05 | Peripheral Neuropathy [https://www.drugs.com/sfx/cisplatin-side-effects.html] |
DILIrank: 3 (Less-DILI-Concern) LiverTox: Likelihood score: C |
NA | NA | Acute Renal Failure [Ozkok and Edelstein, 2014] |
Group 2A http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s053cycl.pdf |
| Cyclopamine | 4449-51-8 | 411.6 | NA | NA | NA | NA | NA | NA |
| Cyclosporin A | 59865-13-3 | 1202.6 | Abducens Nerve Diseases [Pilling et al., 2005] |
DILIrank: 7 (Most-DILI-Concern) LiverTox: Likelihood score: C |
Heart Diseases [Miller, 2002] | NA | Acute Kidney Injury [Humes et al., 1985] |
Group 1 http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s053cycl.pdf |
| Digoxin | 20830-75-5 | 780.9 | Cognition Disorders [Maheut-Bosser et al., 2006] | DILIrank: 0 (No-DILI-Concern) LiverTox: Likelihood score: E |
Heart arrest [Rea et al., 2003] | NA | NA |
Group 2B https://monographs.iarc.who.int/list-of-classifications |
| Doxorubicin | 23214-92-8 | 543.5 | Spinal Cord Diseases [Jordan et al., 2004] |
DILIrank: 3 (Less-DILI-Concern) LiverTox: Likelihood score: B |
Arrhythmias, Cardiac [Mladosievicova et al., 2001] | Albuminuria [Baroni et al., 1999] | NA |
Group 2A https://monographs.iarc.who.int/agents-classified-by-the-iarc/ |
| Gentamicin | 1403-66-3 | 477.6 | Hearing Loss [Sha and Schacht, 1999] | LiverTox: Likelihood score: E | Heart Diseases [Hendry et al., 1988] | NA | Kidney TubularNecrosis, Acute [Xie et al., 2001] | NA |
| Ibuprofen | 15687-27-1 | 206.28 | Meningoencephalitis [Lee et al., 2002] |
DILIrank: 3 (Less-DILI-Concern) LiverTox: Likelihood score: A |
Heart Septal Defects, Ventricular [Cappon et al., 2005] | NA | Kidney TubularNecrosis, Acute [Marasco et al., 1987] | NA |
| Itraconazole | 84625-61-6 | 705.6 | NA |
DILIrank: 8 (Most-DILI-Concern) LiverTox: Likelihood score: B |
Heart Failure [Okuyan and Altin, 2013] | NA | Kidney Diseases [Boelaert et al., 1988] | NA |
| Lithocholic Acid | 434-13-9 | 376.6 | NA | Liver Cirrhosis [Fickert et al., 2006] | NA | NA | NA |
Precancerous Conditions [Kitazawa et al., 1990] [Kitazawa, 1993] Cystic fibrosis [Colombo et al., 2016] |
| Methapyrilene HCl | 135-23-9 | 297.8 | NA | Liver Neoplasms [Ellinger-Ziegelbauer et al., 2005] | NA | NA | NA | Precancerous Conditions [Mizukami et al., 2017] |
| Sunitinib | 557795-19-4 | 398.5 | NA |
DILIrank: 8 (Most-DILI-Concern) LiverTox: Likelihood score: B |
Arrhythmias, Cardiac [Doherty et al., 2013] | Proteinuria [Sorich et al., 2016] | NA | NA |
| Thioacetamide | 62-55-5 | 75.14 | NA |
Hepatic Insufficiency [El-Tanbouly et al., 2017] Liver Cirrhosis [Seong et al., 2003] |
NA | NA | NA |
Group 2B http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s172thio.pdf |
| Valproic Acid | 99-66-1 | 144.21 | CNSDiseases [Ruuskanen et al., 1979] |
DILIrank: 8 (Most-DILI-Concern) LiverTox: Likelihood score: A |
Heart Septal Defects, Atrial [Carter and Stewart, 1989] | NA | Kidney Diseases [Raza et al., 2000] | NA |
| Verapamil HCl | 152-11-4 | 491.1 | NA |
DILIrank: 3 (Less-DILI-Concern) LiverTox: Likelihood score: B |
Ventricular Fibrillation [McGovern et al., 1986] | Kidney Diseases [Ali et al., 2002] | Kidney TubularNecrosis, Acute [Kreft et al., 1991] | NA |
Bold characters indicate positive toxicity.
NT, Neurotoxin; HT, Hepatotoxin; CT, Cardiotoxin; GT, Glomerular toxin (Nephrotoxin); TT, Tubular toxin (Nephrotoxin); NGC, Non-genotoxic carcinogen.
a
Chemical names are given by referring to PubChem (as of April 20, 2021).