REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
anti-GAPDH antibody	Cell Signaling	#2118 RRID: AB_561053
anti-PAR1 antibody	Novus Biologicals	NBP1-71770 RRID: AB_11027203
anti-PAR2 antibody	Abcam	ab180953
anti-Tissue factor antibody	Abcam	ab189483
anti-Factor VII antibody	Abcam	ab97614
anti-p62 antibody	Abcam	ab219581
anti-LC3A/B antibody	Cell Signaling	#4108 RRID:AB_2137703
Hoechst	Life Technologies	33258
horseradish peroxidase-conjugated anti-rabbit immunoglobulin G	Jackson Immunoresearch	#111-035-003 RRID: AB_2313567
horseradish peroxidase-conjugated goat anti-mouse IgG(H + L)	Jackson Immunoresearch	#115-035-003 RRID: AB_10015289
goat anti-rabbit IgG H&L (Cy5)	Abcam	ab97077 RRID: AB_10679461
anti-mouse IgG H&L (Cy5)	Abcam	ab6563 RRID: AB_955068
wheat germ agglutinin-conjugated Alexa Fluor 488	Thermo Fisher Scientific	W11261
dihydroethidium (DHE)	WAKO	041-28251
Bacterial and Virus Strains
AAV-DJ Helper Free Expression System	Cell Biolabs Inc	VPK-410-DJ
Adeno-X Expression System	Clontech	631513
Biological Samples
Human plasma samples	Biobank in Niigata University	N/A
Human BAT samples	Biobank in Zealand University Hospital Køge, Denmark	N/A
Chemicals, Peptides, and Recombinant Proteins
HFD32	CLEA Japan	N/A
Rivaroxaban	Bayer	N/A
Warfarin	Sigma-Aldrich	A2250
MitoSox	Thermo Fisher Scientific	M36008
MitoTracker Green FM	Thermo Fisher Scientific	M7514
MitoTracker Red CM-H2Xros	Thermo Fisher Scientific	M7513
Rhod-2 AM	Thermo Fisher Scientific	R1245MP
human FactorXa protein	Abcam	ab62229
SCH79797	Santa Cruz	sc-203693A
Mito TEMPO	Sigma-Aldrich	SML0737
KB-R7943	TOCRIS Bioscience	1244
FSLLRY-NH2	R&D Systems	4751/1
Critical Commercial Assays
Mouse Coagulation factor Xa ELISA Kit	My BioSource	MBS726968
Human Coagulation factor Xa ELISA Kit	My BioSource	MBS721605
Mouse Tissue Factor ELISA Kit	My BioSource	MBS016365
Factor VII ELISA Kit	My BioSource	MBS944525
Deposited Data
DNA microarray	Gene2015 Jul 1; 565(1):15–21.	GSE64718
Experimental Models: Cell Lines
Brown pre-adipocyte cell line	Gifted from Dr. C. Ronald Kahn (Joslin Diabetes Center and Harvard Medical School)	N/A
Experimental Models: Organisms/Strains
Mouse: Adipoq-Cre+: Pgam1flox/flox Mouse: Ucp1-Cre+/−; PAR1fl/fl (BAT-PAR1 KO)	UCP1-Cre; Rosen and Spiegelman (2014). floxed Par1; Generated in our lab	N/A
Oligonucleotides
Forward primer for mouse Actb; 5′- CTAAGGCCAACCGTGAAAAG-3′	This paper	N/A
Reverse primer for mouse Actb; 5′-ACCAGAGGCATACAGGGACA-3′	This paper	N/A
Forward primer for mouse Rplp0; 5′-GATGCCCAGGGAAGACAG-3′	This paper	N/A
Reverse primer for mouse Rplp0; 5′-ACAATGAAGCATTTTGGATAA-3′	This paper	N/A
Forward primer for mouse Atg5; 5′-AAGTCTGTCCTTCCGCAGTC-3′	This paper	N/A
Reverse primer for mouse Atg5; 5′-TGAAGAAAGTTATCTGGGTAGCTCA-3′	This paper	N/A
Forward primer for mouse Atg7; 5′-CCGGTGGCTTCCTACTGTTA-3′	This paper	N/A
Reverse primer for mouse Atg7; 5′-AAGGCAGCGTTGATGACC-3′	This paper	N/A
Forward primer for mouse Bnip3; 5′-CCTGTCGCAGTTGGGTTC-3′	This paper	N/A
Reverse primer for mouse Bnip3; 5′- GAAGTGCAGTTCTACCCAGGAG-3′	This paper	N/A
Forward primer for mouse F2r;; 5′-G TCTTCCCGCGTCCCTAT-3′	This paper	N/A
Reverse primer for mouse F2r;; 5′- GGGTTCACCGTAGCATCTGT-3′	This paper	N/A
Forward primer for mouse F2rl1; 5′- GGACCGAGAACCTTGCAC-3′	This paper	N/A
Reverse primer for mouse F2rl1; 5′- GGAACCCCTTTCCCAGTG-3′	This paper	N/A
Forward primer for mouse F10; 5′-C CATCTTGAATGAGTTCTACATCCT-3′	This paper	N/A
Reverse primer for mouse F10; 5′-TT CTCTGTGTTCCGATCACCT-3′	This paper	N/A
Forward primer for mouse F7; 5′-CG CTACTGGGGAAACATCAC-3′	This paper	N/A
Reverse primer for mouse F7; 5′-CC CCATCCTTCTCACTGAAG-3′	This paper	N/A
Forward primer for mouse F3; 5′-G CTCAAGCACGGGAAAGA-3′	This paper	N/A
Reverse primer for mouse F3; 5′-G CTTGCACAGAGATATGGACAG-3′	This paper	N/A
Forward primer for mouse F12; 5′-T GGGGTCACCAGTTCGAG-3′	This paper	N/A
Reverse primer for mouse F12; 5′-A GGGAACCTGTGCCTCCT-3′	This paper	N/A
Forward primer for mouse F11 5′-GGTGCTTGCTCTTCACGTT-3′	This paper	N/A
Reverse primer for mouse F11 5′-TCAGGATGCAGGCAAACC-3′	This paper	N/A
Forward primer for mouse F9; 5′-C GCTACTGGGGAAACATCAC-3′	This paper	N/A
Reverse primer for mouse F9; 5′-C CCCATCCTTCTCACTGAAG-3′	This paper	N/A
Forward primer for mouse F8; 5′-A GATACACTTACCCTGTTCCCATT-3′	This paper	N/A
Reverse primer for mouse F8; 5′-A CCCCAAGACCCATAGACCT-3′	This paper	N/A
Forward primer for mouse F5; 5′-G GACCAGAGGGGTGTACAGA-3′	This paper	N/A
Reverse primer for mouse F5; 5′-T GTTCTCGTCAAACACAGCAA-3′	This paper	N/A
Forward primer for mouse F2; 5′-G CAGTGTCCCTGTCTGTGG-3′	This paper	N/A
Reverse primer for mouse F2; 5′-T TGTCCTTGGAACCTCCAGA-3′	This paper	N/A
Forward primer for mouse Fga; 5′-G CAGGAAGCGAAGCTCAC-3′	This paper	N/A
Reverse primer for mouse Fga; 5′-T GGAGGACATCATCACAGTCTC-3′	This paper	N/A
Forward primer for mouse Fgb; 5′-G CCGATGATGACTACGATGA-3′	This paper	N/A
Reverse primer for mouse Fgb; 5′-A GGTCTTAGGCTAGGAGGCTCT-3′	This paper	N/A
Forward primer for mouse Fgg; 5′-G GCCACCTCAATGGAGTTTA-3′	This paper	N/A
Reverse primer for mouse Fgg; 5′-C ATGGTGGTTTCCTTCATAGAAT-3′	This paper	N/A
Forward primer for mouse F13a1; 5′-T TCAGAGTGGAATATGTCATTGGT-3′	This paper	N/A
Reverse primer for mouse F13a1; 5′-A CAGGCACAGGGATGTAGGT-3′	This paper	N/A
Forward primer for mouse F13b; 5′-A CTGCCCCCTGAGTGTGTT-3′	This paper	N/A
Reverse primer for mouse F13b; 5′-A ACAACCACACCGTTTGCTA-3′	This paper	N/A
Forward primer for mouse Map1c3a; 5′-C CCCACCAAGATCCCAGT-3′	This paper	N/A
Reverse primer for mouse Map1c3a; 5′- CGCTCATGTTCACGTGGT-3′	This paper	N/A
Recombinant DNA
pCMV6-Kan/Neo-mouse F3	OriGENE	MC200642
pCMV6-Entry-mouse F2r	OriGENE	MR206862
Software and Algorithms
SPSS version 24 software	IBM	N/A
KEGG mapper	KEGG (Kyoto Encyclopedia of Genes and Genomes)	N/A