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. 2022 May 20;298(7):102059. doi: 10.1016/j.jbc.2022.102059

Figure 6.

Figure 6

Knockdown Snail expression rescues EMT induced by silencing of RORα.A, EMT marker proteins, RORα and Snail, were examined in control, RORα-silenced, and Snail-/RORα-silenced MCF10A cells. B, immunofluorescence images of RORα-silenced and Snail-/RORα-silenced MCF10A cells. Bar represents 50 μm. C, transwell invasion analysis of control, RORα-silenced, and Snail-/RORα-silenced MCF10A cells; n = 4. ∗∗p < 0.01. Bar represents 100 μm. D, analysis of mammosphere formation in control, RORα-silenced, and Snail/RORα both silenced MCF10A cells. n = 4. ∗∗p < 0.01. Bar represents 200 μm. EMT, epithelial–mesenchymal transition; RORα, retinoid orphan nuclear receptor alpha.