Table 1.
In vitro antiproliferative activities of the target compounds 6a–6x
| Compound | IC50 (μM) |
||
|---|---|---|---|
| A549 | SGC-7901 | MCF-7 | |
| 6a | 9.34 | 3.16 | 0.219 |
| 6b | 0.292 | 0.285 | 1.06 |
| 6c | 1.45 | 1.06 | 0.542 |
| 6d | 0.850 | >10 | 0.106 |
| 6e | 1.04 | 0.272 | 0.244 |
| 6f | 17.7 | >30 | 0.219 |
| 6g | 0.985 | 0.126 | 0.257 |
| 6h | 0.063 | 0.120 | 0.094 |
| 6i | 0.211 | 0.117 | 0.130 |
| 6j | 2.42 | 0.535 | 1.74 |
| 6k | 4.26 | 1.68 | 1.99 |
| 6l | 0.755 | 0.098 | 0.497 |
| 6m | 0.150 | 0.120 | 0.116 |
| 6n | 2.05 | 2.48 | 1.41 |
| 6o | 1.43 | 2.78 | 0.999 |
| 6p | 5.99 | 7.69 | 4.90 |
| 6q | 0.848 | 0.570 | 0.324 |
| 6r | 1.15 | 1.08 | 0.194 |
| 6s | >30 | 0.595 | 4.21 |
| 6t | 0.825 | 1.07 | 0.203 |
| 6u | >30 | 2.93 | 3.10 |
| 6v | 0.496 | 3.25 | 4.94 |
| 6w | 0.932 | 0.964 | 2.01 |
| 6x | 5.06 | 0.394 | 4.68 |
| Colchicinea | 0.107 | 0.043 | 0.059 |
| SMARTa | 0.089 | 0.019 | 0.048 |
a
Used as positive controls.