TABLE 3.
Pharmacodynamic parameters
| Parameter | Adolescent (N = 38) | Adult (N = 37) |
|---|---|---|
| Serum potassium | ||
| C min (mmol/L) | 4.17 (0.370)a | 3.91 (0.306)b |
| AUC0–2h (h·mmol/L) | 8.83 (0.584)c | 8.34 (0.629)b |
| AUC0–t (h·mmol/L) | 17.6 (1.14)d | 16.6 (1.28)b |
| t min (h) | 2.00 (0.00; 4.00)e | 2.02 (0.00; 4.05)b |
| Serum glucose | ||
| C max (mmol/L) | 7.09 (1.49) | 7.78 (1.60) |
| AUC0–2h (h·mmol/L) | 10.4 (0.923) | 11.3 (1.20) |
| AUC0–t (h·mmol/L) | 22.7 (2.33) | 25.0 (3.11) |
| t max (h) | 4.00 (0.00; 4.08) | 4.02 (2.02; 4.05) |
| Heart rate (bpm) | ||
| HR0–4h | 81.6 (12.0) | 82.8 (11.9) |
| Change from baseline | 4.9 (6.2) | 3.7 (6.2) |
| HR0–12h | 85.4 (11.6) | 84.8 (11.0) |
| Change from baseline | 8.1 (6.2) | 6.3 (7.6) |
| HR0–24h | 79.9 (9.8) | 77.3 (8.5) |
| Change from baseline | 2.8 (6.8) | −1.0 (7.1) |
Note: Data are arithmetic mean (SD), except t min and t max, which are median (range). n = a35, b36, c29, d25, e35. C min, minimum serum concentration; AUC, area under the curve from 0 to 2 h (0–2 h), and 0 to the last quantifiable concentration (0–t); t min, time to minimum serum concentration; C max, maximum serum concentration; t max, time to maximum serum concentration; HR, heart rate.