TABLE 2.
Comparison of receiver operating characteristic curve analysis for IgA, IgM, and total IgG against Mce1A protein and IgM anti-PGL-I in discriminating among new HD patients, treated HD patients and HHC vs. endemic controls.
| Group | Antibody | AUC (95%CI) | p-value | Cut-off (O.D) |
Sensitivity% (95%CI) | Specificity% (95%CI) | LR + |
| IgA | 0.95 | <0.0001 | 0.203 | 93.2 (74.8–99.0) | 88.2 (72.5–96.7) | 7.8 | |
| IgM | 0.83 | <0.0001 | 0.184 | 57.6 (36.9–76.6) | 85.0 (62.1–96.7) | 3.8 | |
| PAR-NC | IgG | 0.97 | <0.0001 | 0.302 | 88.4 (69.8–97.5) | 100 (83.1–100) | − |
| APGL-I | 0.81 | 0.0002 | 0.295 | 38.4 (20.2–59.4) | 100 (83.1–100) | − | |
| IgA | 0.80 | 0.0012 | 0.203 | 52.6 (28.8–75.5) | 100 (83.1–100) | − | |
| IgM | 0.60 | 0.27 | 0.184 | 100 (82.3–100) | 15 (3.2–37.8) | 1.1 | |
| CAR-TP | IgG | 0.99 | <0.0001 | 0.302 | 94⋅7 (73.9–99.8) | 100 (83.1–100) | − |
| APGL-I | 0.60 | 0.26 | 0.295 | 10.5 (1.3–33.1) | 100 (83.1–100) | − | |
| IgA | 0.92 | <0.0001 | 0.203 | 82.3 (56.5–96.2) | 100 (83.2–100) | − | |
| IgM | 0.64 | 0.12 | 0.184 | 58.8 (32.9–81.5) | 60 (36.0–80.8) | 1.4 | |
| HHC | IgG | 0.96 | <0.0001 | 0.302 | 88.2 (63.5–98.5) | 100 (83.1–100) | − |
| APGL-I | 0.67 | 0.06 | 0.295 | 11.7 (1.4–36.4) | 100 (83.1–100) | − |
AUC, area under the receiver operating characteristic curve; CI, confidence interval; O.D, optical density; LR+, positive likelihood ratio; PAR-NC, new cases of HD in Parnaíba; CAR-TP, patients treated in Colony Carpina; HHC household contacts of HD patients in Parnaíba.