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. 2022 Jun 8;35:103075. doi: 10.1016/j.nicl.2022.103075

Table 2.

Brainnetome atlas regions for which the average SDI is significantly different between healthy subjects and participants with 22q11DS. The first column indicates the region’s location in the brain, while the second column indicates the brain region’s name (BA = Brodmann Area) with the correspondent region’s IDs of the Brainnetome atlas (third column). The average SDI value for healthy controls (SDI_HC), the average SDI value for participants with 22q11DS (SDI_22q11DS), the adjusted p-values (q-value) after correction for multiple comparisons are also list in the following columns. Finally, we report in the last columns the average structural nodal strength which consists of sum of all connections for a certain region. Structural nodal strength was reported for healthy controls (SC_HC) and for 22q11DS (SC_22q11DS) with the respective adjusted p-value (q-value) after multiple comparisons. For region withs significantly different SDI values, the average correlation coefficient between SDI and motion (in terms of mean frame-wise displacement after scrubbing) is reported.

Higher average FSD in 22q11DS(SDI_22q11DS < SDI_HC)
Region’s location Region's name (hemisphere) Region's ID SDI_HC SDI_22q11DS q-value (FDR) SC_HC SC_22q11DS q-value (FDR)
Superior Frontal Gyrus medial BA 8 (L) 2 0.92 0.80 0.0153 0.0048 0.0052 >0.05
dorsolateral BA 6 (R) 8 1.10 0.97 0.0325 0.0045 0.0049 0.0428
Orbital Gyrus lateral BA 11 (L) 45 0.92 0.82 0.0325 0.0062 0.0072 0.0004
Paracentral Lobule BA 4 (R) 68 0.67 0.58 0.0195 0.0042 0.0043 >0.05
Inferior Temporal Gyrus intermediate lateral BA 20 (L) 95 1.43 1.14 0.0133 0.0015 0.0021 0.0000
intermediate lateral BA 20 (R) 96 1.28 1.05 0.0139 0.0017 0.0021 0.0284
Superior Parietal Lobule postcentral BA 7 (R) 132 0.93 0.78 0.0071 0.0038 0.0041 >0.05
Inferior Parietal Lobule caudal BA 39 (L) 135 0.83 0.73 0.0150 0.0053 0.0057 >0.05
Precuneus medial BA 5 (L) 150 0.82 0.72 0.0325 0.0040 0.0037 >0.05
Insular Gyrus dorsal granular insula (R) 172 0.84 0.75 0.0324 0.0024 0.0027 0.0063
dorsal dysgranular insula (R) 174 0.78 0.66 0.0409 0.0024 0.0030 0.0000
Lateral Occipital Cortex middle occipital gyrus (L) 199 0.69 0.59 0.0116 0.0056 0.0053 >0.05
middle occipital gyrus (R) 200 0.68 0.58 0.0195 0.0049 0.0048 >0.05
BA V5/MT+ (L) 201 0.97 0.87 0.0409 0.0050 0.0048 >0.05
medial superior occipital gyrus (R) 208 0.80 0.70 0.0139 0.0052 0.0048 0.0373
Hippocampus rostral hippocampus (R) 216 0.78 0.68 0.0228 0.0052 0.0051 >0.05
Basal Ganglia ventral caudate (R) 220 0.95 0.83 0.0116 0.0052 0.0060 0.0000
dorsolateral putamen (R) 230 0.85 0.75 0.0071 0.0079 0.0087 0.0000
Thalamus medial pre-frontal thalamus (R) 232 2.62 2.36 0.0149 0.0013 0.0015 0.0006
rostral temporal thalamus (R) 238 2.06 1.87 0.0409 0.0025 0.0024 >0.05
Lower average FSD in 22q11DS(SDI_22q11DS > SDI_HC)
Region’s location Region's name (hemisphere) Region's ID SDI_HC SDI_22q11DS q-value (FDR) SC_HC SC_22q11DS q-value (FDR)
Middle Frontal Gyrus BA 46 (L) 19 0.78 0.92 0.0089 0.0046 0.0047 >0.05
BA 46 (R) 20 0.71 0.82 0.0090 0.0044 0.0047 >0.05
Inferior Frontal Gyrus rostral BA 45 (L) 35 0.84 1.03 0.0022 0.0025 0.0026 >0.05
rostral BA 45 (R) 36 0.85 1.02 0.0071 0.0025 0.0025 >0.05
opercular BA 44 (L) 37 0.72 0.85 0.0071 0.0035 0.0035 >0.05
Orbital Gyrus lateral BA 12/47 (L) 51 0.57 0.71 0.0003 0.0048 0.0054 0.0000
lateral BA 12/47 (R) 52 0.68 0.78 0.0332 0.0037 0.0042 0.0001
Precentral Gyrus BA 4
(tongue and larynx region) (L) 61 0.71 0.79 0.0325 0.0035 0.0037 >0.05
Auditory Cortex TE1.0 and TE1.2 (L) 73 0.56 0.66 0.0078 0.0039 0.0039 >0.05
Superior Temporal Gyrus lateral BA 38 (R) 78 0.89 1.03 0.0230 0.0027 0.0028 >0.05
Inferior Temporal Gyrus extreme lateroventral BA37 (L) 91 0.75 0.86 0.0484 0.0030 0.0030 >0.05
extreme lateroventral BA37 (R) 92 0.84 1.03 0.0253 0.0017 0.0015 >0.05
ventrolateral BA 37 (L) 97 0.91 1.06 0.0205 0.0033 0.0031 >0.05
ventrolateral BA 37 (R) 98 0.95 1.10 0.0228 0.0027 0.0024 0.0297
Precuneus medial BA 7 (L) 147 0.77 0.87 0.0149 0.0034 0.0031 >0.05
medial BA 5 (L) 151 0.46 0.54 0.0025 0.0069 0.0059 0.0000
BA 31 (L) 153 0.66 0.75 0.0149 0.0054 0.0051 >0.05
Insular Gyrus dorsal agranular insula (L) 167 1.14 1.29 0.0196 0.0019 0.0019 >0.05
dorsal BA 23 (L) 175 0.90 1.01 0.0186 0.0034 0.0032 >0.05
dorsal BA 23 (R) 176 0.97 1.08 0.0189 0.0030 0.0027 0.0041
Cingulate Cortex rostroventral BA 24 (L) 177 0.89 1.06 0.0071 0.0047 0.0048 >0.05
rostroventral BA 24 (R) 178 0.69 0.83 0.0027 0.0066 0.0065 >0.05
pregenual BA 32 (L) 179 0.96 1.22 0.0000 0.0027 0.0023 0.0000
pregenual BA 32 (R) 180 1.17 1.40 0.0055 0.0021 0.0017 0.0000
ventral BA 23 (L) 181 0.75 0.86 0.0183 0.0045 0.0044 >0.05
ventral BA 23 (R) 182 0.79 0.89 0.0440 0.0039 0.0038 >0.05
subgenual BA 32 (L) 187 0.75 0.91 0.0022 0.0043 0.0039 0.0284
subgenual BA 32 (R) 188 0.88 1.13 0.0000 0.0025 0.0021 0.0011
Framewise displacement correlation with SDI
Correlation coefficient (r-value), Average (standard deviation) P- value
Areas with significantly different SDI in the groups HC 22q11DS
2.46e-17 (1.02e-16) 4.32e-18 (7.63e-17) 0.3502