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. 2022 Jun 9;13:830312. doi: 10.3389/fphar.2022.830312

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Copyright © 2022 Ren, Wang, Guo, Chen, Wu, Gu, Xu, Wu and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Microcystin (MC)-RR inhibits TGF-β-induced epithelial dedifferentiation and myofibroblast differentiation in vitro. (A,B) Cultured HK2 (human proximal tubular cell) and NRK-49F (rat kidney fibroblasts) were treated with MC-RR (0.1 μM) for 48 h. The uptake of MC-RR by HK2 and NRK-49F cells was detected by immunofluorescence (scale bar: 40 μm). (C,D) HK2 and NRK-49F cells were left alone or cultured with TGF-β1 (5 ng/ml) to induce epithelial dedifferentiation and myofibroblast activation. Some of the cultured cells were also treated with 0.1 μM MC-RR for 48 h. The expression levels of the marker proteins used for assessment of epithelial dedifferentiation and myofibroblast activation in the cultured HK2 or NRK-49F cells were detected by western blot.