TABLE 11.
Pharmacokinetic parameters of tetramethylpyrazine, ferulic acid, nodakenin, and isoimperatorin in powder group and pill group (n = 3,−x ± S).
| Pharmacokinetic parameters | Powder group (ng/ml) | Pill group (ng/ml) | ||||||
|---|---|---|---|---|---|---|---|---|
| Tetramethylpyrazine | Ferulic acid | Nodakenin | Isoimperatorin | Tetramethylpyrazine | Ferulic acid | Nodakenin | Isoimperatorin | |
| AUC0-t (ng/L*h) | 21.30 ± 4.27 | 3676.20 ± 1,113.23 | 338.17 ± 153.41 | 8.34 ± 2.45 | 22.37 ± 19.27 | 8,668.75 ± 6,388.07 | 697.92 ± 115.84 | 9.83 ± 9.05 |
| AUC0-∞(ng/L*h) | 39.94 ± 17.10 | 5,766.23 ± 1,929.36 | 601.98 ± 191.55 | 9.91 ± 1.98 | 55.08 ± 69.44 | 9,727.90 ± 5,946.39 | 1,667.63 ± 1,720.98 | 14.64 ± 15.07 |
| MRT0-t(h) | 12.01 ± 2.87 | 10.98 ± 0.52 | 9.27 ± 1.08 | 5.14 ± 0.98 | 11.08 ± 1.45 | 8.75 ± 1.69 | 9.37 ± 1.89 | 9.42 ± 2.70 |
| MRT0-∞(h) | 26.00 ± 15.78 | 18.27 ± 12.62 | 10.74 ± 8.95 | 9.34 ± 0.52 | 14.29 ± 7.19 | 15.53 ± 6.89 | 39.72 ± 52.30 | 17.26 ± 8.11 |
| t 1/2 (h) | 15.29 ± 7.57 | 7.66 ± 4.80 | 7.09 ± 5.31 | 8.48 ± 1.77 | 8.78 ± 3.87 | 8.42 ± 4.39 | 27.03 ± 37.60 | 12.83 ± 8.95 |
| T max (h) | 12.83 ± 10.77 | 1.33 ± 1.44 | 0.22 ± 0.24 | 1.33 ± 0.76 | 3.75 ± 3.93 | 3.17 ± 0.76 | 4.17 ± 3.75 | 0.67 ± 0.29 |
| C max (ng/L) | 2.13 ± 1.17 | 354.83 ± 203.60 | 31.93 ± 13.06 | 3.20 ± 1.23 | 2.30 ± 2.11 | 1124.30 ± 667.80 | 56.03 ± 12.96 | 2.23 ± 2.07 |