TABLE 5.
Cumulative dissolution rates of tetramethylpyrazine, ferulic acid, nodakenin, and isoimperatorin (n = 3, −x ± S).
| Times (min) | Powder group (ng/ml) | Pill group (ng/ml) | ||||||
|---|---|---|---|---|---|---|---|---|
| Tetramethylpyrazine | Ferulic acid | Nodakenin | Isoimperatorin | Tetramethylpyrazine | Ferulic acid | Nodakenin | Isoimperatorin | |
| 2 | 0.89 ± 0.07 | 29.08 ± 1.77 | 44.64 ± 1.96 | 0.14 ± 0.00 | 0.08 ± 0.00 | 1.69 ± 0. 52 | 3.34 ± 1.34 | 0.11 ± 0.02 |
| 5 | 0.96 ± 0.18 | 40.00 ± 0.69 | 48.01 ± 1.30 | 0.17 ± 0.00 | 0.08 ± 0.01 | 2.19 ± 0.30 | 4.33 ± 1.49 | 0.12 ± 0.02 |
| 15 | 1.05 ± 0.19 | 43.31 ± 2.65 | 48.72 ± 0.52 | 0.16 ± 0.01 | 0.24 ± 0.11 | 6.79 ± 0.86 | 8.06 ± 2.64 | 0.13 ± 0.04 |
| 30 | 1.10 ± 0.17 | 43.52 ± 3.90 | 49.08 ± 1.71 | 0.15 ± 0.02 | 0.26 ± 0.03 | 12.12 ± 2.43 | 11.97 ± 3.11 | 0.14 ± 0.04 |
| 45 | 0.94 ± 0.02 | 42.26 ± 0.60 | 49.01 ± 0.27 | 0.16 ± 0.01 | 0.29 ± 0.05 | 17.51 ± 2.25 | 14.68 ± 4.76 | 0.14 ± 0.01 |
| 60 | 0.91 ± 0.06 | 40.81 ± 3.83 | 48.02 ± 1.22 | 0.18 ± 0.03 | 0.33 ± 0.00 | 22.18 ± 0.84 | 22.22 ± 3.04 | 0.15 ± 0.02 |
| 90 | 0.90 ± 0.04 | 42.00 ± 0.23 | 49.21 ± 1.61 | 0.17 ± 0.02 | 0.47 ± 0.14 | 24.92 ± 2.35 | 26.96 ± 4.62 | 0.13 ± 0.01 |
| 120 | 1.03 ± 0.22 | 48.02 ± 1.92 | 49.85 ± 1.34 | 0.22 ± 0.04 | 0.45 ± 0.00 | 35.31 ± 2.96 | 35.34 ± 0.56 | 0.14 ± 0.00 |
| 150 | 1.08 ± 0.15 | 43.37 ± 1.00 | 49.94 ± 1.24 | 0.13 ± 0.01 | 0.48 ± 0.01 | 36.83 ± 2.53 | 38.43 ± 3.82 | 0.14 ± 0.00 |
| 180 | 1.08 ± 0.17 | 46.41 ± 3.00 | 50.02 ± 0.80 | 0.18 ± 0.01 | 0.51 ± 0.01 | 42.07 ± 0.29 | 41.65 ± 3.04 | 0.15 ± 0.00 |
| 210 | 0.98 ± 0.02 | 45.96 ± 3.50 | 46.89 ± 4.23 | 0.16 ± 0.01 | 0.54 ± 0.01 | 47.88 ± 4.01 | 42.73 ± 3.97 | 0.15 ± 0.00 |
| 240 | 1.01 ± 0.05 | 55.60 ± 1.35 | 50.62 ± 1.24 | 0.17 ± 0.02 | 0.53 ± 0.05 | 52.64 ± 3.97 | 45.76 ± 2.68 | 0.14 ± 0.02 |