TABLE 1.
Patient’s characteristics, treatment and diagnostics.
| Days | 0 | 3 | 14 | 21 | 28 | 42 | 56 | 70 | 73 | 77 |
|---|---|---|---|---|---|---|---|---|---|---|
| Olamkicept infusion (600 mg) | x | — | x | — | x | x | x | x | — | — |
| 18Fluorodeoxyglucose positron emission tomography/computed tomography—whole body | x | — | — | — | — | — | — | — | — | x |
| Leukocytes [x109/L] | 10.7 | 10.4 | 10.2 | 10.8 | 11.0 | 10.7 | 11.9 | 10.3 | 8.54 | 11.0 |
| Immature granulocytes [x109/L] | 0.03 | 0.05 | 0.03 | 0.04 | 0.04 | 0.05 | 0.06 | 0.04 | 0.04 | 0.05 |
| Neutrophils [x109/L] | 7.3 | 6.9 | 7.1 | 7.3 | 7.7 | 7.6 | 8.2 | 7.2 | 5.4 | 7.8 |
| Eosinophils [x109/L] | 0.2 | 0.4 | 0.2 | 0.3 | 0.2 | 0.2 | 0.2 | 0.1 | 0.2 | 0.2 |
| Basophils [x109/L] | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 |
| Lymphocytes [x109/L] | 2.5 | 2.5 | 2.3 | 2.5 | 2.4 | 2.3 | 3.7 | 2.3 | 2.5 | 2.2 |
| Monocytes [x109/L] | 0.6 | 0.5 | 0.6 | 0.6 | 0.6 | 0.6 | 0.6 | 0.6 | 0.4 | 0.6 |
| Haemoglobin [g/dL] | 15.6 | 16.7 | 15.7 | 16.1 | 15.7 | 15.3 | 15.5 | 15.9 | 15.6 | 16.1 |
| Platelets [x109/L] | 200 | 203 | 173 | 179 | 193 | 175 | 178 | 195 | 84 | 191 |
| Sodium [mmol/L] | 141 | 140 | 143 | 143 | 139 | 140 | 144 | 140 | — | — |
| Potassium [mmol/L] | 3.84 | 3.75 | 3.91 | 3.99 | 4.05 | 3.94 | 4.03 | 3.92 | — | — |
| Calcium, albumin-corrected [mmol/L] | 2.38 | 2.44 | 2.44 | — | — | — | 2.54 | 2.49 | — | 2.4 |
| Glomerular filtration rate [mL/min/1.73] | 60 | 68 | 60 | 67 | 73 | 63 | 60 | 63 | — | — |
| Apolipoprotein B [mg/dL] | 51 | – | 56.0 | 61.0 | 53.0 | 51.0 | 51.0 | 53.0 | — | 66.0 |
| Bilirubin [µmol/L] | 7.4 | 8.3 | 9.1 | 9.0 | 7.4 | 8.5 | 5.1 | 8.8 | — | — |
| Creatine kinase [U/L] | 42 | 37 | 28 | 37 | 30 | 27 | 54 | 35 | — | — |
| Alanine aminotransferase [U/L] | 13.8 | 15.5 | 15.0 | 16.8 | 13.0 | 19.0 | 15.9 | 13.8 | — | — |
| γ-glutamyl transferase [U/L] | 40 | 41 | 32 | 39 | 39 | 37 | 38 | 40 | — | — |
| Lipase [U/L] | 33 | 41 | 33 | 34 | 36 | 32 | 29 | 33 | — | — |
| International Normalized Ratio | 1.01 | — | 1.02 | 0.99 | 0.96 | 1.05 | 1.01 | 1.06 | — | — |
| D-dimer [mg/L] | 0.34 | — | 0.31 | 0.34 | 0.47 | 0.32 | 0.26 | 0.32 | — | — |
| Cholesterol [mmol/L] | 2.7 | 3.1 | 2.9 | 3.1 | 2.9 | 2.6 | 2.6 | 2.7 | — | 3.0 |
| HDL cholesterol [mmol/L] | 1.0 | 1.15 | 1.08 | 1.05 | 1.03 | 0.97 | 1.04 | 0.97 | — | 1.19 |
| LDL cholesterol [mmol/L] | 1.3 | 1.65 | 1.4 | 1.62 | 1.36 | 1.21 | 1.27 | 1.34 | — | 1.48 |
| Triglycerides [mmol/L] | 2.2 | 2.2 | 2.0 | 2.4 | 2.0 | 2.2 | 2.1 | 2.2 | — | 1.7 |
| Lipoprotein (a) [nmol/L] | 238.7 | 250.2 | 227.2 | 236.7 | 241.1 | 234.2 | 225.7 | 243.0 | — | 231.7 |
| hsCRP (high-sensitivity C-reactive protein) [mg/dL] | 9.18 | 3.33 | 12.7 | 7.06 | 9.99 | 11.2 | 18.9 | 14.4 | 4.1 | 7.14 |
| Interleukin-6 [pg/mL] | 4.8 | 32.0 | 9.8 | 24.3 | 12.0 | 11.7 | 15.5 | 11.7 | 40.6 | 26.8 |
| Soluble interleukin-6 receptor [ng/mL] | 60.84 | — | 61.18 | — | 66.67 | 70.45 | 53.86 | 60.84 | 64.15 | 54.54 |
| Soluble gp130 (including olamkicept) [ng/mL] | 319.12 | — | 983.41 | — | 1,094.79 | 1,281.33 | 1,061.24 | 1,014.27 | 2,620.65 | 1865.10 |
| IL-11 [pg/ml] | < LOD | — | < LOD | — | < LOD | < LOD | < LOD | < LOD | < LOD | < LOD |
| HbA1c (glycated hemoglobin) [%] | 6.7 | — | — | — | — | — | — | — | — | 6.5 |
<LOD, below the limit of detection.