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. 2022 Jun 9;13:909828. doi: 10.3389/fneur.2022.909828

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Copyright © 2022 Luo, Ma, Guo, Yu, Jia, Zhang, Feng and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Establishment of the miRNA/TF/mRNA axis and gene set enrichment analysis (GSEA). (A) Volcano plot showing the differential expression of miRNAs that regulate TF in molecular interaction networks. (B) Sankey diagram showing the core miRNA/TF/mRNA regulatory axis. (C,D) ROC curves showing the ability of (C) HDAC7 (AUC:0.859) and (D) ACTN4 (AUC:0.755) to distinguish between SIC and HC. (E,F) ROC curves showing the ability of (E) HDAC7 (AUC:0.809) and (F) ACTN4 (AUC:0.705) to distinguish between HF and HC. (G,H) GSEA results for (G) HDAC7 and (H) ACTN4.