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. 2022 Jun 9;9:916607. doi: 10.3389/fnut.2022.916607

TABLE 2.

Riboflavin biosynthesis pathway genes present in the L. reuteri AMBV339 genome.

Gene product involved in riboflavin synthesis or metabolism Gene ontology (GO) in PATRIC Contig Start End Length, bp
Genes required for riboflavin synthesis according to the KEGG database
3,4-dihydroxy-2-butanone 4-phosphate synthase (EC 4.1.99.12)/GTP cyclohydrolase II (EC 3.5.4.25) GO:0008686/
GO:0003935
1598.1216.con.0004 70,789 71,970 1,182
Diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26)/5-amino-6-(5-phosphoribosylamino) uracil reductase (EC 1.1.1.193) GO:0008835/
GO:0008703
1598.1216.con.0004 69,136 70,194 1,059
Hydrolase, HAD superfamily (3.1.3.104) 1598.1216.con.0013 834 1,652 819
6,7-dimethyl-8-ribityllumazine synthase (EC 2.5.1.78) 1598.1216.con.0004 71,973 72,431 459
Riboflavin synthase eubacterial/eukaryotic (EC 2.5.1.9) GO:0004746 1598.1216.con.0004 70,187 70,789 603
FMN adenylyltransferase (EC 2.7.7.2)/Riboflavin kinase (EC 2.7.1.26) GO:0003919/
GO:0008531
1598.1216.con.0016 22,505 23,452 948
Additional genes involved in riboflavin transport or metabolism
RibT protein, riboflavin biosynthesis acetyltransferase (GNAT) family 1598.1216.con.0004 10,251 10,607 357
Substrate-specific component RibU of riboflavin ECF transporter 1598.1216.con.0004 13,069 13,647 579