Table 1.
Comparison of clinicopathological data: SD- versus LD-type iCCAs
| Clinicopathological data | Total (n = 140) | SD type (n = 93) | LD type (n = 47) | p value |
|---|---|---|---|---|
| Age, year* | 64.4±8.5 | 63.7±8.2 | 65.6±9.0 | 0.227 |
| Sex (men: women) | 98: 42 | 67: 26 | 31: 16 | 0.458 |
| CA 19–9* | 22.3 (0.0–29,000.0) | 17.0 (0.0–7,600.0) | 1,214.5 (2.0–29,000.0) | <0.001 |
| CEA* | 2.4 (0.0–1,121.0) | 2.2 (0.0–46.0) | 4.5 (0.0–1,121.0) | 0.109 |
| AFP* | 3.4 (0.0–1,710.0) | 3.3 (0.0–809.0) | 3.5 (1.3–1,710.0) | 0.469 |
| Chronic liver disease | 55 (39.3) | 49 (52.7) | 6 (12.8) | <0.001 |
| Chronic hepatitis B | 37 (67.3) | 32 (65.3) | 5 (83.3) | |
| Chronic hepatitis C | 3 (5.5) | 3 (6.1) | 0 (0.0) | |
| Alcoholic liver disease | 5 (9.1) | 4 (8.2) | 1 (16.7) | |
| Nonalcoholic fatty-liver disease | 10 (18.2) | 10 (20.4) | 0 (0.0) | |
| Liver cirrhosis | 10 (7.1) | 8 (8.6) | 2 (4.3) | 0.495 |
| Biliary stone | 2 (1.4) | 0 (0) | 2 (4.3) | 0.111 |
| Biliary dysplasia | 19 (13.6) | 3 (3.2) | 16 (34.0) | <0.001 |
| Macroscopic feature | ||||
| MF type, purely | 124 (88.6) | 92 (98.9) | 32 (68.1) | <0.001 |
| MF combined with the PI or IG type† | 16 (11.4) | 1 (1.1) | 15 (31.9) | |
| Median size, cm* | 4.6 (1.0–18.5) | 4.0 (1.0–13.0) | 5.5 (2.0–18.5) | 0.001 |
| T stage | ||||
| 1, 2 | 96 (68.6) | 73 (78.5) | 23 (48.9) | <0.001 |
| 3, 4 | 44 (31.4) | 20 (21.5) | 24 (51.1) | |
| N stage | ||||
| 0 | 111 (79.3) | 80 (86.0) | 31 (66.0) | 0.006 |
| 1, 2 | 29 (20.7) | 13 (14.0) | 16 (34.0) | |
| Differentiation | ||||
| Well, moderate | 107 (76.4) | 71 (76.3) | 36 (76.6) | 0.974 |
| Poor | 33 (23.6) | 22 (23.7) | 11 (23.4) | |
| Multiplicity | ||||
| Single | 113 (80.7) | 80 (86.0) | 33 (70.2) | 0.025 |
| Multiple | 27 (19.3) | 13 (14.0) | 14 (29.8) | |
| Necrosis | 88 (62.9) | 52 (55.9) | 36 (76.6) | 0.017 |
| Venous invasion | 67 (47.9) | 34 (36.6) | 33 (70.2) | <0.001 |
| Perineural invasion | 54 (38.6) | 23 (24.7) | 31 (66.0) | <0.001 |
| Operation type | ||||
| Minor | 50 (35.7) | 39 (41.9) | 11 (23.4) | 0.031 |
| Major (lobectomy and hepatectomy) | 90 (64.3) | 54 (58.1) | 36 (76.6) | |
| Positive resection margin | 19 (13.6) | 8 (8.6) | 11 (23.4) | 0.016 |
Unless otherwise indicated, data are numbers of patients, with percentages in parentheses. Categorical variables were compared using the χ2 test or Fisher exact test, as appropriate. CA19-9, carbohydrate antigen 19-9; CEA, carcinoembryonic antigen; AFP, alpha-fetoprotein; MF, mass-forming; PI, periductal infiltrative; IG, intraductal growing. * Data are continuous variables, reported as means ± standard deviations or median (range) values, and were compared using the Student's t test.
†
There was 1 case of MF type combined with intraductal growing type in the LD type. The others were MF type combined with periductal infiltrative type.