Table 3.
Univariate and multivariate analyses of MRI features in discriminating LD-type iCCA
| MR imaging data | Univariate |
Multivariate |
||||
|---|---|---|---|---|---|---|
| OR | 95% CI | p value | OR | 95% CI | p value | |
| Median size (cm) | 1.130 | 0.995, 1.283 | 0.060 | |||
| Location (center) | 0.143 | |||||
| Peripheral | ||||||
| Midzone | 0.959 | 0.278, 3.311 | 0.947 | |||
| Central/diffuse | 5.395 | 1.001, 29.071 | 0.050 | |||
| Location (perihilar border) | 0.002 | |||||
| Peripheral | ||||||
| Midzone | 2.760 | 1.007, 7.567 | 0.048 | |||
| Central/diffuse | 4.601 | 1.985, 10.661 | <0.001 | |||
| Contour | ||||||
| Round/lobulated | ||||||
| Infiltrative | 18.621 | 5.116, 67.775 | <0.001 | 14.176 | 2.459, 81.708 | 0.003* |
| Liver surface change | 0.654 | 0.299, 1.430 | 0.287 | |||
| BD dilatation | <0.001 | 0.066 | ||||
| No dilatation | ||||||
| Peritumoral dilatation | 8.691 | 3.665, 20.610 | <0.001 | 2.382 | 0.779, 7.279 | 0.128 |
| Diffuse dilatation | 17.778 | 2.992, 105.641 | 0.002 | 9.673 | 1.217, 76.890 | 0.032* |
| Liver cirrhosis | 1.034 | 0.487, 2.199 | 0.930 | |||
| AP enhancement pattern | <0.001 | 0.006* | ||||
| Nonrim APHE | ||||||
| Rim APHE | 0.977 | 0.381, 2.503 | 0.961 | 1.569 | 0.423, 5.824 | 0.501 |
| No APHE | 14.844 | 3.886, 56.706 | <0.001 | 17.848 | 2.685, 118.643 | 0.003* |
| Peritumoral arterial enhancement | 2.917 | 1.264, 6.730 | 0.012 | |||
| Delayed central enhancement | 1.469 | 0.620, 3.479 | 0.382 | |||
| Portal phase washout pattern | 0.034 | |||||
| No washout | ||||||
| Peripheral washout | 0.139 | 0.031, 0.630 | 0.011 | |||
| Nonperipheral washout | 0.694 | 0.291, 1.652 | 0.409 | |||
| TP appearance | 0.003 | |||||
| No hypointensitiy | ||||||
| Targetoid appearance | 0.143 | 0.046, 0.446 | 0.001 | |||
| Nontargetoid hypointensity | 0.563 | 0.232, 1.363 | 0.203 | |||
| HBP appearance | ||||||
| Targetoid appearance | ||||||
| Nontargetoid hypointensity | 2.133 | 1.044, 4.357 | 0.038 | |||
| Diffusion-weighted imaging appearance | 0.007 | |||||
| Targetoid restriction | ||||||
| Marked diffusion restriction | 0.965 | 0.334, 2.788 | 0.947 | |||
| Restriction, but nontargetoid nor marked | 3.628 | 1.548, 8.504 | 0.003 | |||
| Vascular invasion | 8.667 | 3.354, 22.398 | <0.001 | 4.477 | 1.298, 15.441 | 0.018* |
| Multiplicity | 2.394 | 1.028, 5.572 | 0.043 | |||
| Regional lymph node metastasis | 2.206 | 0.958, 5.081 | 0.063 | |||
| Necrosis or mucin | 1.234 | 0.600, 2.537 | 0.568 | |||
OR, odds ratio; APHE, arterial phase hyperenhancement.
*
Statistically significant results from logistic regression analysis. Variables with p < 0.05 on univariate logistic regression analysis were utilized as input variables for multivariate logistic regression analysis.