TABLE 4.
Chemical structures of complexes 16–24 and IC50 of complexes toward different cancer cell lines.
| Complex | R1 | R2 | λmax/nm of the LMCT band (N3→Pt) | λirr/nm | Cell line | IC50 (light)/μM | IC50 (dark)/μM | PI IC50 (dark)/IC50 (light) | Reference | |
|---|---|---|---|---|---|---|---|---|---|---|
|
16 | NH2CH2CH2NH2 | 315 | 366/365 | 5637 | 63.0 ± 20.2 | 440 ± 143 | 7.0 | Bednarski et al., (2007); Farrer et al., (2010a) | |
| 5637-CDDP | 79.8 ± 16.6 | >200 | >2.5 | |||||||
| A2780 | 16 ± 1 | 67 ± 8 | 4.2 | |||||||
| A2780cis | 22 ± 3 | 82 ± 8 | 3.7 | |||||||
| 17 | NH3 | NH3 | 256 | 366 | 5637 | 49.3 ± 28.1 | 357 ± 81 | 7.2 | Bednarski et al., (2007); Bednarski et al., (2006); Farrer et al., (2010a) | |
| — | 5637-CDDP | 79.8 ± 16.6 | >200 | 2.5 | ||||||
| 365 | HaCaT | 169.3 | >287.9 | >1.7 | ||||||
| — | A2780 | 135.1 | 287.9 | 2.1 | ||||||
| — | A2780cis | 204.9 | 287.9 | 1.4 | ||||||
| 21 | NH3 |
|
257 | 365 | HaCaT | 203.9 | >256.9 | >1.3 | — | |
| A2780 | 93.4 | >256.9 | >2.8 | |||||||
| 22 | NH3 |
|
258 | 365 | HaCaT | 149.9 | >247.9 | >1.7 | Farrer et al. (2010a) | |
| 23 | NH3 |
|
258 | 365 | HaCaT | 224.3 | >239.6 | >1.1 | — | |
| A2780 | >239.6 | >239.6 | — | |||||||
| A2780cis | >239.6 | >239.6 | — | |||||||
|
18 | NH3 | NH3 | 285 | 365 | HaCaT | 121.2 | >287.9 | >2.4 | Farrer et al. (2010a) |
| A2780 | 99.2 | >287.9 | >2.9 | |||||||
| A2780cis | 163.6 | >287.9 | >1.8 | |||||||
| 19 | NH3 | MeNH2 | 286 | 420 | HaCaT | 163.3 | >276.8 | >1.7 | Farrer et al. (2010a); Mackay et al. (2009b) | |
| 365 | HaCaT | 65.5 | >276.8 | >4.2 | ||||||
| — | A2780 | 39.8 | >276.8 | >7.0 | ||||||
| — | A2780cis | 128.7 | >276.8 | >2.2 | ||||||
| 20 | NH3 | EtNH2 | 285 | 420 | HaCaT | 98.3 | >266.5 | >2.7 | — | |
| 365 | HaCaT | 68.3 | >266.5 | >3.9 | ||||||
| — | A2780 | 58.4 | >266.5 | >4.6 | ||||||
| — | A2780cis | 90.1 | >266.5 | >3.0 | Westendorf et al. (2011) | |||||
| 24 | NH3 |
|
287.5 | 366 | 5637 | 29.17 ± 2.23 | >80 | >2.7 | ||
The bold values represent the numbering of the complexes.