TABLE 5.
Chemical structures of complexes 25–43 and IC50 values of complexes toward different cancer cell lines.
| Complex | R1 | R2 | λmax/nm of the LMCT band (N3→Pt) | λirr/nm | Cell line | IC50 (light)/μM | IC50 (dark)/μM | PI IC50 (dark)/IC50 (light) | References | |
|---|---|---|---|---|---|---|---|---|---|---|
|
25 | NH3 | Py | 258 | 365 | HaCaT | 100.9 | >244.4 | >2.4 | Farrer et al. (2010a) |
| 420 | 116.5 | >244.4 | >2.1 | |||||||
| 365 | A2780 | 79.6 | >244.4 | >3.1 | ||||||
| 365 | A2780cis | 108.7 | >244.4 | >2.3 | ||||||
| 27 | NH3 |
|
258 | 365 | HaCaT | 131.0 | >236.3 | >1.8 | Farrer et al. (2010a) | |
| 420 | 89.9 | >236.3 | >2.6 | |||||||
| 365 | A2780 | 65.9 | >236.3 | >3.6 | ||||||
| A2780cis | 165.2 | >236.3 | >1.4 | |||||||
| 29 | NH3 |
|
259 | 365 | HaCaT | >236.2 | >236.2 | — | Farrer et al. (2010a) | |
| A2780 | 63.6 | >236.2 | >3.7 | |||||||
| A2780cis | >236.2 | >236.2 | — | |||||||
|
26 | NH3 | Py | 289 | 365 | HaCaT | 6.8 | >244.4 | >35.9 | Farrer et al., (2010a); Pizarro et al., (2014) |
| 420 | — | 85.9 | >244.4 | >2.8 | ||||||
| 365 | A2780 | 1.9 | >244.4 | >128.6 | ||||||
| 420 | — | 25.4 | >244.4 | >9.6 | ||||||
| 365 | A2780cis | 16.9 | >244.4 | >14.5 | ||||||
| 365 | OE19 | 10.0 | >244.4 | >24.4 | ||||||
| 420 | — | 32.0 | >244.4 | >7.6 | ||||||
| 28 | NH3 |
|
292 | 365 | HaCaT | 54.0 | >236.3 | >4.4 | Farrer et al., (2010a); Mackay et al., (2009b); Wootton et al., (2018) | |
| A2780 | 51.0 | >236.3 | >4.6 | |||||||
| A2780cis | 59.7 | >236.3 | >4.0 | |||||||
| 30 | NH3 |
|
289 | 365 | HaCaT | 22.0 | 144.1 | 6.6 | Wootton et al. (2018) | |
| 420 | — | 14.6 | 144.1 | 9.9 | ||||||
| 365 | A2780 | 2.6 | 26.8 | 10.3 | ||||||
| — | A2780cis | 2.9 | 57.7 | 19.9 | ||||||
| 31 | NH3 |
|
289 | 365 | HaCaT | 7.1 | 97.8 | 13.8 | Farrer et al., (2010a); Mackay et al., (2009a) | |
| 420 | — | 11.9 | 97.8 | 8.2 | ||||||
| 365 | A2780 | 4.2 | 108.7 | 25.9 | ||||||
| — | A2780cis | 5.4 | 134.9 | 25.0 | ||||||
| 32 | NH3 |
|
287 | 365 | HaCaT | 61.0 | 108.0 | 1.8 | Farrer et al. (2010a) | |
| A2780 | 15.8 | 31.3 | 2.0 | |||||||
| A2780cis | 38.2 | 54.4 | 1.4 | |||||||
| 33 | NH3 |
|
289 | 365 | HaCaT | 4.5 | >241.0 | >53.6 | Mackay et al., (2009b); Zhao et al. (2013) | |
| 420 | HaCaT | 19.8 | >241.0 | >12.2 | ||||||
| 365 | A2780 | 5.5 | 186.9 | 34.0 | ||||||
| — | A2780cis | 9.9 | >241.0 | >24.3 | ||||||
| 34 | MeNH2 | Py | 289 | 365 | HaCaT | 2.6 | >236.3 | >90.8 | ||
| 420 | — | 14.7 | >236.3 | >16.0 | ||||||
| 365 | A2780 | 2.3 | >236.3 | >102.7 | ||||||
| 420 | — | 6.6 | >236.3 | >35.8 | ||||||
| 365 | A2780cis | 4.4 | >236.3 | >53.7 | ||||||
| 420 | — | 13.2 | >236.3 | >17.9 | ||||||
| 365 | OE19 | 10.1 | >236.3 | >23.4 | ||||||
| 420 | — | 13.9 | >236.3 | >17.0 | ||||||
| 35 | MeNH2 |
|
289 | 365 | HaCaT | 3.5 | >232.9 | >66.5 | — | |
| 420 | 11.2 | >232.9 | >20.7 | |||||||
| 365 | A2780 | 3.2 | >232.9 | >72.8 | ||||||
| 420 | 28.2 | >232.9 | >8.3 | |||||||
| 365 | A2780cis | 5.3 | >232.9 | >43.9 | ||||||
| 420 | 6.4 | >232.9 | >36.4 | |||||||
| 365 | OE19 | 6.2 | >232.9 | >37.6 | ||||||
| 420 | 19.3 | >232.9 | >12.1 | |||||||
| 36 | Py | Py | 294 | 365 | HaCaT | 1.4 | >212.3 | >151.6 | Farrer et al., (2010b); Farrer et al., (2010a); Zhao et al., (2013) | |
| 420 | — | 9.5 | >212.3 | >22.3 | ||||||
| 365 | A2780 | 1.4 | >212.3 | >151.6 | ||||||
| 420 | — | 8.3 | >212.3 | >25.6 | ||||||
| 365 | A2780cis | 14.5 | >212.3 | >14.6 | ||||||
| 365 | OE19 | 4.7 | >212.3 | >25 | ||||||
| 420 | — | 8.4 | >212.3 | >45 | ||||||
| 365 | HepG2 | 2.5 | >212.3 | >85 | ||||||
| 465 | A2780 | 7.1 ± 0.4 | >100 | >14.1 | ||||||
| — | A549 | 51.9 ± 2.5 | >100 | >1.9 | ||||||
| — | PC3 | 55.6 ± 0.9 | >100 | >1.8 | ||||||
| — | MRC5 | — | >100 | — | ||||||
| 37 |
|
Py | 292 | 420 | A2780 | 14.5 | 105.9 | 7.3 | Mackay et al. (2009b) | |
| A2780cis | 15.5 | 82.2 | 5.3 | |||||||
| 38 |
|
Py | 294 | 420 | A2780 | 4.0 | >206.0 | >51.5 | — | |
| A2780cis | 3.3 | >234.3 | >71.0 | |||||||
| OE19 | 5.5 | >209.0 | >38 | |||||||
| 39 |
|
Py | 294 | 420 | A2780 | 5.4 | >205.2 | >38 | — | |
| A2780cis | 4.6 | >207.0 | >45 | |||||||
| OE19 | 12.3 | >209.1 | >17 | |||||||
| 40 |
|
|
295 | 420 | A2780 | 7.2 | >200.2 | >27.8 | — | |
| A2780cis | 10.4 | >200.7 | >19.3 | — | ||||||
| 41 |
|
|
293 | 420 | A2780 | 2.1 | >199.5 | >95 | — | |
| A2780cis | 4.1 | >200.1 | >48.8 | |||||||
| OE19 | 8.2 | >196.8 | >24 | |||||||
| 42 |
|
|
295 | 420 | A2780 | 2.4 | 115.2 | 48 | — | |
| A2780cis | 2.9 | >205.9 | >71.0 | |||||||
| OE19 | 7.6 | >205.2 | >27 | |||||||
| 43 |
|
|
290 | 420 | A2780 | 56.3 | >208.3 | >3.7 | — | |
| A2780cis | 164.2 | >213.5 | >1.3 | |||||||
|
44 |
|
— | 318 | 365 | A2780 | 3.3 ± 0.3 | 57 ± 6 | 17.3 | Kasparkova et al. (2015) |
| A2780cis | 3.9 ± 0.5 | 18 ± 5 | 4.6 | |||||||
| 420 | A2780 | 8.4 ± 0.4 | 31 ± 2 | 3.7 | ||||||
| A2780cis | 10.2 ± 0.2 | 24.2 ± 0.7 | 2.4 |
The bold values represent the numbering of the complexes.