TABLE 7.
IC50 values of complexes 60—74 to various cancer cell lines.
| Complex | λmax/nm of the LMCT band (N3→Pt) | λirr/nm | Cell line | IC50 (light)/μM | IC50 (dark)/μM | PI IC50 (dark)/IC50 (light) | Reference |
|---|---|---|---|---|---|---|---|
| 60 | 400–450 | 650 | A2780 | 0.13 ± 0.01 | >10 | 76.9 | Wang et al. (2019) |
| A2780cisR | 0.19 ± 0.01 | >10 | 52.6 | ||||
| MCF-7 | 0.044 ± 0.004 | >10 | 227.3 | ||||
| 4T1 | 0.13 ± 0.004 | >10 | 76.9 | ||||
| MRC-5 | — | >10 | — | ||||
| 61 | 400–500 | 450 | HCT116 (p53+/+) | 52.8 ± 6.6 | >100 | 1.9 | Deng et al. (2020) |
| HCT116 p53−/− | 89.3 ± 5.6 | >100 | 1.1 | ||||
| HT29 | 81.5 ± 5.5 | >100 | 1.2 | ||||
| HeLa | 61.8 ± 4.8 | >100 | 1.6 | ||||
| MCF-7 | 86.2 ± 9.3 | >100 | 1.2 | ||||
| MDA-MB-231 | 79.4 ± 6.6 | >100 | 1.3 | ||||
| A2780 | 56.2 ± 5.6 | >100 | 1.8 | ||||
| A2780cisR | >100 | >100 | — | ||||
| A549 | 81.3 ± 6.7 | >100 | 1.2 | ||||
| A549cisR | >100 | >100 | — | ||||
| MRC5 | — | >100 | — | ||||
| 62 | 400–500 | 450 | HCT116 (p53+/+) | 0.9 ± 0.2 | 47.1 ± 5.9 | 52 | Deng et al. (2020) |
| HCT116 p53−/− | 1.3 ± 0.3 | 80.6 ± 7.1 | 62 | ||||
| HT29 | 2.7 ± 0.4 | 51.6 ± 4.2 | 19 | ||||
| HeLa | 5.6 ± 1.1 | 38.8 ± 4.2 | 7 | ||||
| MCF-7 | 5.5 ± 2.1 | 52.1 ± 6.9 | 10 | ||||
| MDA-MB-231 | 8.1 ± 3.0 | 69.3 ± 5.2 | 9 | ||||
| A2780 | 3.9 ± 0.6 | 42.1 ± 4.7 | 11 | ||||
| A2780cisR | 4.9 ± 0.8 | 72.6 ± 4.8 | 15 | ||||
| A549 | 6.9 ± 1.1 | 49.2 ± 4.2 | 7 | ||||
| A549cisR | 4.0 ± 0.5 | 114.8 ± 7.7 | 29 | ||||
| MRC5 | — | 93.9 ± 6.8 | — | ||||
| 63 | 500–600 | Visible light (400–760 nm) | A2780 | 44 ± 5 | 220 ± 17 | 5.0 | Deng et al. (2020) |
| A2780cisR | 41 ± 5 | 250 ± 18 | 6.1 | ||||
| MCF-7 | 77 ± 9 | 245 ± 17 | 3.2 | ||||
| A549 | 57 ± 5 | 251 ± 15 | 4.4 | ||||
| A549cisR | 61 ± 6 | 289 ± 17 | 4.7 | ||||
| HCT116 | 47 ± 5 | 248 ± 18 | 5.3 | ||||
| MRC-5 | — | >300 | — | ||||
| 64 | 500–600 | Visible light (400–760 nm) | A2780 | 25 ± 2 | 108 ± 9 | 4.3 | Deng et al. (2021) |
| A2780cisR | 20 ± 7 | 136 ± 13 | 6.8 | ||||
| MCF-7 | 43 ± 3 | 133 ± 11 | 3.1 | ||||
| A549 | 29 ± 5 | 104 ± 15 | 3.6 | ||||
| A549cisR | 33 ± 5 | 142 ± 10 | 4.3 | ||||
| HCT116 | 18 ± 1 | 112 ± 6 | 6.2 | ||||
| MRC-5 | — | 116 ± 7 | — | ||||
| 65 | 504 | White light | A2780 | >100 | >100 | — | Yao et al. (2020) |
| 66 | 503 | White light | A2780 | 43.9 ± 5.2 | 69.8 ± 4.9 | 1.6 | |
| 67 | 503 | White light | A2780 | 48.3 ± 2.0 | 74.8 ± 8.2 | 1.5 | |
| 68 | 503 | White light | A2780 | 76.8 ± 9.9 | >100 | 1.3 | |
| 69 | 504 | White light | A2780 | >100 | >100 | — | |
| 70 | 505 | White light | A2780 | 66.6 ± 7.0 | >100 | 1.5 | Bera et al., (2021); Wang et al., (2019) |
| Green light | MCF-7 | 173.4 ± 8.8 | 15.7 ± 1.0 | 11.0 | |||
| MDA-MB-231 | 162 ± 8.4 | 19.1 ± 4.7 | 8.5 | ||||
| SKOV3 | >200 | 22.4 ± 0.8 | >8.9 | ||||
| A2780 | 68.5 ± 5.0 | 31.0 ± 7.1 | 2.2 | ||||
| HeLa | >200 | 37 ± 1.5 | >5.4 | ||||
| A549 | 148.9 ± 17.3 | 60.5 ± 14 | 2.5 | ||||
| WI-38 | >200 | — | — | ||||
| 71 | 503 | White light | A2780 | 43.8 ± 3.9 | >100 | 2.3 | Wang et al. (2019) |
| 72 | 503 | White light | A2780 | 88.6 ± 15.7 | >100 | 1.1 | |
| 73 | 504 | White light | A2780 | >100 | >100 | — | |
| 74 | 504 | White light | A2780 | >100 | >100 | — |